Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.37 |
| ▸ | TRPV3 | Q8NET8 | 4/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | STK17B | O94768 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 2/20 | 0.34 |
| ▸ | PPARA | Q07869 | 2/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2245501 | 0.83 | CCR1 (0.40) | CCR1STK17BJAK2PSEN1PSEN2 | |
| SCHEMBL6385846 | 0.81 | FBP1 (0.39) | CCR1FFAR1STK17BJAK2PSEN1 | |
| SCHEMBL6383912 | 0.78 | KCNH2 (0.39) | CCR1FFAR1STK17BJAK2PPARD | |
| SCHEMBL13780397 | 0.78 | AKR1C3 (0.41) | CCR1FFAR1TRPV3STK17BJAK2 | |
| SCHEMBL3957943 | 0.78 | AKR1C3 (0.41) | CCR1FFAR1TRPV3STK17BJAK2 | |
| SCHEMBL2244394 | 0.77 | CCR1 (0.40) | CCR1FFAR1STK17BJAK2ESR1 | |
| SCHEMBL6383920 | 0.77 | KCNH2 (0.39) | CCR1FFAR1STK17BJAK2PPARD | |
| SCHEMBL3960372 | 0.74 | PDE2A (0.38) | TRPV3PDE2ASTK17BAKR1C3AKR1C2 | |
| SCHEMBL6387932 | 0.74 | CCR1 (0.38) | CCR1FFAR1STK17BJAK2PPARD | |
| SCHEMBL2654304 | 0.74 | RXRA (0.47) | TRPV3AKR1C3AKR1C2PSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1583754-A1 | THIOPHENE DERIVATIVE PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-10-12 | — | — | EP | disclosed |
| WO-2004063184-A1 | THIOPHENE DERIVATIVE PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2004-07-29 | — | — | WO | disclosed |