Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10153047 | 0.89 | CYP2D6 (0.44) | CHRNB2CHRNA4CHRNB4CHRNA3PDE4B | |
| SCHEMBL12999220 | 0.86 | CYP2D6 (0.45) | ALDH1A1CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL15469635 | 0.85 | MEN1 (0.55) | ALDH1A1MEN1MAPTKMT2APDE4B | |
| SCHEMBL15469641 | 0.85 | MEN1 (0.55) | ALDH1A1MEN1MAPTKMT2APDE4B | |
| SCHEMBL12597751 | 0.85 | MEN1 (0.55) | ALDH1A1MEN1MAPTKMT2APDE4B | |
| SCHEMBL15298467 | 0.81 | CHRNB2 (0.52) | CHRNB2CHRNA4CHRNB4CHRNA3PDE4B | |
| SCHEMBL24777816 | 0.80 | CYP2D6 (0.38) | ALDH1A1CA1CA2EPHX2CA12 | |
| SCHEMBL21340435 | 0.80 | CYP2D6 (0.38) | ALDH1A1KMT2ACA1CA2EPHX2 | |
| SCHEMBL13781667 | 0.80 | EPHX2 (0.46) | ALDH1A1MAPTCHRNB2CHRNA4CHRNA3 | |
| SCHEMBL9917273 | 0.80 | EPHX2 (0.46) | ALDH1A1MAPTCHRNB2CHRNA4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090176307-A1 | Compounds, Compositions and Methods | CYTOKINETICS, INC. | 2009-07-09 | — | — | US | disclosed |
| US-7491826-B2 | Compounds, compositions and methods | CYTOKINETICS, INC. (US) | 2009-02-17 | — | — | US | disclosed |
| US-7399866-B2 | Compounds, compositions, and methods | CYTOKINETICS, INC. (US) | 2008-07-15 | — | — | US | disclosed |