Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15298463 | 0.81 | MAPT (0.37) | GAARAB9AKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL13781667 | 0.80 | EPHX2 (0.46) | SMN1; SMN2CYP2D6ALDH1A1KCNH2HRH3 | |
| SCHEMBL13781666 | 0.80 | EPHX2 (0.46) | SMN1; SMN2CYP2D6ALDH1A1KCNH2HRH3 | |
| SCHEMBL21340435 | 0.80 | CYP2D6 (0.38) | KMT2ASMN1; SMN2CYP2D6ALDH1A1KCNH2 | |
| SCHEMBL28240876 | 0.80 | CYP2D6 (0.38) | KMT2ASMN1; SMN2CYP2D6ALDH1A1KCNH2 | |
| SCHEMBL24777816 | 0.80 | CYP2D6 (0.38) | SMN1; SMN2CYP2D6ALDH1A1KCNH2HRH3 | |
| SCHEMBL9917273 | 0.80 | EPHX2 (0.46) | SMN1; SMN2CYP2D6ALDH1A1KCNH2HRH3 | |
| SCHEMBL13781646 | 0.79 | CYP2D6 (0.41) | KMT2AMEN1SMN1; SMN2CYP2D6ALDH1A1 | |
| SCHEMBL12384401 | 0.79 | ALDH1A1 (0.41) | KMT2AMEN1CYP2D6ALDH1A1KCNH2 | |
| SCHEMBL23710179 | 0.79 | ALDH1A1 (0.41) | KMT2AMEN1CYP2D6ALDH1A1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090176307-A1 | Compounds, Compositions and Methods | CYTOKINETICS, INC. | 2009-07-09 | — | — | US | disclosed |
| US-7491826-B2 | Compounds, compositions and methods | CYTOKINETICS, INC. (US) | 2009-02-17 | — | — | US | disclosed |
| US-7399866-B2 | Compounds, compositions, and methods | CYTOKINETICS, INC. (US) | 2008-07-15 | — | — | US | disclosed |