Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VDR | P11473 | 9/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3392464 | 0.84 | HDAC3 (0.50) | VDRHDAC3HDAC6 | |
| SCHEMBL3392542 | 0.82 | HDAC3 (0.53) | VDRHDAC3HDAC6 | |
| SCHEMBL13786176 | 0.79 | HDAC3 (0.34) | VDRHDAC3HDAC6 | |
| SCHEMBL3392112 | 0.75 | HDAC3 (0.49) | VDRHDAC3HDAC6 | |
| SCHEMBL3391355 | 0.74 | HDAC3 (0.53) | VDRHDAC3HDAC6 | |
| SCHEMBL13366707 | 0.74 | HDAC6 (0.61) | VDRHDAC3HDAC6 | |
| SCHEMBL13709353 | 0.73 | VDR (0.42) | VDRHDAC3HDAC6 | |
| SCHEMBL3392743 | 0.70 | ESR1 (0.45) | VDRHDAC3HDAC6 | |
| SCHEMBL13786177 | 0.70 | HDAC3 (0.33) | HDAC3HDAC6 | |
| SCHEMBL3393336 | 0.70 | HDAC3 (0.54) | VDRHDAC3HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1511740-B1 | PHENYL-THIOPHENE TYPE VITAMIN D RECEPTOR MODULATORS | LILLY CO ELI (US) | 2009-07-08 | — | — | EP | disclosed |