Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | HDAC1 | Q13547 | 12/20 | 0.64 |
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.64 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.64 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.64 |
| ▸ | NCOR2 | Q9Y618 | 5/20 | 0.64 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.60 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.60 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.57 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | BRD4 | O60885 | 1/20 | 0.54 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8082660 | 0.87 | MEN1 (0.86) | MEN1KMT2AHDAC1HDAC8HDAC2 | |
| SCHEMBL17480780 | 0.80 | HDAC1 (0.78) | HDAC1HDAC8HDAC2HDAC3NCOR2 | |
| SCHEMBL13159743 | 0.78 | MMP8 (0.62) | MEN1KMT2AHDAC1HDAC8HDAC2 | |
| SCHEMBL2942358 | 0.78 | MEN1 (0.96) | MEN1KMT2AGAAEPHX2CYP3A4 | |
| SCHEMBL8285463 | 0.77 | HDAC1 (0.64) | MEN1KMT2AHDAC1HDAC8HDAC2 | |
| SCHEMBL13965275 | 0.77 | MEN1 (0.63) | MEN1KMT2AHDAC1HDAC8HDAC2 | |
| SCHEMBL8286916 | 0.77 | HDAC1 (0.64) | MEN1KMT2AHDAC1HDAC8HDAC2 | |
| SCHEMBL3999895 | 0.77 | HDAC1 (0.68) | MEN1KMT2AHDAC1HDAC8HDAC2 | |
| SCHEMBL3994291 | 0.77 | HDAC1 (0.68) | MEN1KMT2AHDAC1HDAC8HDAC2 | |
| SCHEMBL5807174 | 0.77 | HDAC1 (1.00) | HDAC1HDAC8HDAC2HDAC3NCOR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2083005-A1 | Carbamic acid compounds comprising an amide linkage as HDAC inhibitors | TopoTarget UK Limited (GB) | 2009-07-29 | — | — | EP | disclosed |