Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 1/20 | 0.63 |
| ▸ | GSK3B | P49841 | 3/20 | 0.47 |
| ▸ | AURKA | O14965 | 2/20 | 0.47 |
| ▸ | GSK3A | P49840 | 2/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.44 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.44 |
| ▸ | INSR | P06213 | 1/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2061066 | 0.84 | ALK (0.55) | CSNK2A2CSNK2BCSNK2A1INSRALK | |
| SCHEMBL267189 | 0.83 | EGFR (0.50) | CSNK2A2CSNK2BCSNK2A1INSRALK | |
| SCHEMBL23754828 | 0.82 | ALK (0.48) | GSK3BCSNK2A2CSNK2BCSNK2A1MEN1 | |
| SCHEMBL2302190 | 0.82 | SCN9A (0.58) | AURKACSNK2A2CSNK2BCSNK2A1SCN9A | |
| SCHEMBL30086205 | 0.82 | ALK (0.48) | GSK3BCSNK2A2CSNK2BCSNK2A1MEN1 | |
| SCHEMBL656001 | 0.82 | PIN1 (0.72) | PIN1GSK3BAURKAGSK3AMAPT | |
| SCHEMBL19958511 | 0.82 | PIN1 (0.72) | PIN1GSK3BAURKAGSK3AMAPT | |
| SCHEMBL19877901 | 0.81 | PIN1 (0.71) | PIN1GSK3BAURKAGSK3AJAK2 | |
| SCHEMBL13794335 | 0.80 | CSNK2A1 (0.48) | CSNK2A2CSNK2BCSNK2A1INSRALK | |
| SCHEMBL13303630 | 0.79 | PIN1 (0.72) | PIN1GSK3BAURKAGSK3AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7563781-B2 | Triazolopyrimidine derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2009-07-21 | — | — | US | disclosed |
| US-20070015207-A1 | Triazolopyrimidine derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2007-01-18 | — | — | US | disclosed |
| US-20070015207-A1 | Triazolopyrimidine derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2007-01-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070015207-A1 | Triazolopyrimidine derivatives | ABL1, FLT3, ROS1 | PIN1 1213/4885GSK3B 389/4885AURKA 456/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.