Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 11/20 | 1.00 |
| ▸ | BACE1 | P56817 | 11/20 | 1.00 |
| ▸ | KDM1A | O60341 | 1/20 | 0.74 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.72 |
| ▸ | AURKA | O14965 | 3/20 | 0.65 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11882354 | 0.94 | ACHE (0.88) | ACHEBACE1PDE10AAURKAENPP1 | |
| SCHEMBL13529592 | 0.89 | ACHE (0.80) | ACHEBACE1KDM1APDE10AAURKA | |
| SCHEMBL3873291 | 0.88 | ACHE (0.78) | ACHEBACE1PDE10AAURKAENPP1 | |
| SCHEMBL5518977 | 0.87 | ACHE (0.76) | ACHEBACE1PDE10AAURKAENPP1 | |
| SCHEMBL5525750 | 0.85 | ACHE (0.74) | ACHEBACE1PDE10AAURKAENPP1 | |
| SCHEMBL25679271 | 0.85 | ACHE (0.74) | ACHEBACE1KDM1APDE10AAURKA | |
| SCHEMBL20828299 | 0.85 | TLR9 (0.77) | ACHEBACE1KDM1A | |
| SCHEMBL12255609 | 0.85 | ACHE (0.73) | ACHEBACE1PDE10AAURKAENPP1 | |
| SCHEMBL2389420 | 0.84 | ACHE (0.72) | ACHEBACE1PDE10AENPP1ALDH1A1 | |
| SCHEMBL27338891 | 0.84 | ACHE (0.72) | ACHEBACE1PDE10AAURKAENPP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8552018-B2 | Substituted tricyclic compounds as protein kinase inhibitors | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2013-10-08 | — | — | US | disclosed |
| US-20090143399-A1 | Protein Kinase Inhibitors | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2009-06-04 | — | — | US | disclosed |
| US-20090099165-A1 | Protein Kinase Inhibitors | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2009-04-16 | — | — | US | disclosed |
| US-20080051414-A1 | Protein Kinase Inhibitors | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2008-02-28 | — | — | US | disclosed |
| US-7326712-B2 | Substituted tricyclic compounds as protein kinase inhibitors | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2008-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099165-A1 | Protein Kinase Inhibitors | CDK2, MAP3K1, MAP3K2 | ACHE 4778/4885BACE1 2284/4885KDM1A 835/4885 |
| US-20080051414-A1 | Protein Kinase Inhibitors | CDK2, MAP3K1, MAP3K2 | ACHE 4778/4885BACE1 2284/4885KDM1A 835/4885 |
| US-20090143399-A1 | Protein Kinase Inhibitors | CDK2, MAP3K1, MAP3K2 | ACHE 4778/4885BACE1 2284/4885KDM1A 835/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.