Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.56 |
| ▸ | GSK3B | P49841 | 3/20 | 0.55 |
| ▸ | BACE1 | P56817 | 2/20 | 0.55 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.55 |
| ▸ | TTR | P02766 | 2/20 | 0.55 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | CA12 | O43570 | 3/20 | 0.53 |
| ▸ | CA7 | P43166 | 3/20 | 0.53 |
| ▸ | CA9 | Q16790 | 3/20 | 0.53 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA4 | P22748 | 2/20 | 0.53 |
| ▸ | CA6 | P23280 | 2/20 | 0.53 |
| ▸ | CA5A | P35218 | 2/20 | 0.53 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6539315 | 0.90 | GSK3B (0.68) | KDM4ENR1H4GSK3BBACE1AKR1B10 | |
| SCHEMBL6539306 | 0.90 | GSK3B (0.68) | KDM4ENR1H4GSK3BBACE1AKR1B10 | |
| SCHEMBL5757598 | 0.89 | ALDH1A1 (0.72) | KDM4EALDH1A1PKMNR1H4AKR1B10 | |
| SCHEMBL5757599 | 0.89 | ALDH1A1 (0.72) | KDM4EALDH1A1PKMNR1H4AKR1B10 | |
| SCHEMBL1481115 | 0.88 | BACE1 (0.61) | KDM4EALDH1A1PKMGSK3BBACE1 | |
| SCHEMBL1481113 | 0.88 | BACE1 (0.61) | KDM4EALDH1A1PKMGSK3BBACE1 | |
| SCHEMBL13678668 | 0.86 | ALDH1A1 (0.55) | KDM4EALDH1A1PKMNR1H4GSK3B | |
| SCHEMBL11815273 | 0.86 | TTR (0.62) | KDM4EALDH1A1TTRLMNACA12 | |
| SCHEMBL11815268 | 0.86 | TTR (0.62) | KDM4EALDH1A1TTRLMNACA12 | |
| SCHEMBL1481374 | 0.84 | KDM4E (0.77) | KDM4EALDH1A1PKMGSK3BBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7553867-B2 | Furan or thiophene derivative and medicinal use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-06-30 | — | — | US | disclosed |