Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.52 |
| ▸ | EED | O75530 | 1/20 | 0.52 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.52 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.52 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.52 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 3/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
| ▸ | STS | P08842 | 1/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.44 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31602756 | 0.82 | GPR119 (0.56) | GPR119EEDRBBP4SUZ12EZH2 | |
| SCHEMBL19617395 | 0.82 | GPR119 (0.49) | GPR119EEDRBBP4SUZ12EZH2 | |
| SCHEMBL30607205 | 0.82 | GPR119 (0.49) | GPR119EEDRBBP4SUZ12EZH2 | |
| SCHEMBL21050110 | 0.82 | GPR119 (0.49) | GPR119EEDRBBP4SUZ12EZH2 | |
| SCHEMBL3786536 | 0.81 | EED (0.50) | GPR119EEDRBBP4SUZ12EZH2 | |
| SCHEMBL1249505 | 0.81 | EED (0.50) | GPR119EEDRBBP4SUZ12EZH2 | |
| SCHEMBL1249503 | 0.81 | EED (0.50) | GPR119EEDRBBP4SUZ12EZH2 | |
| SCHEMBL3852714 | 0.81 | EED (0.50) | GPR119EEDRBBP4SUZ12EZH2 | |
| SCHEMBL14065612 | 0.80 | GPR119 (0.51) | GPR119KDM4EPKMIDO1STS | |
| SCHEMBL22558670 | 0.79 | GPR119 (0.59) | GPR119EEDRBBP4SUZ12EZH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7541368-B2 | 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-{3-[1-(1-methyl-cyclopropanecarbonyl)-piperidin-4-ylmethyl]-phenyl}-urea; use in the treatment of disease states capable of being modulated by the inhibition of p38 kinase and tumor necrosis factor (TNF) | AVENTIS PHARMACEUTICALS INC. (US) | 2009-06-02 | — | — | US | disclosed |