Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CMA1 | P23946 | 1/20 | 0.46 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | TNF | P01375 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | RGS4 | P49798 | 1/20 | 0.42 |
| ▸ | RGS8 | P57771 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3996653 | 0.89 | CMA1 (0.47) | CMA1GSK3AGSK3BSMN1; SMN2CXCR4 | |
| SCHEMBL13793064 | 0.89 | CMA1 (0.47) | CMA1GSK3AGSK3BSMN1; SMN2CXCR4 | |
| SCHEMBL13793062 | 0.89 | ALDH1A1 (0.54) | CMA1SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL13793156 | 0.88 | TNF (0.47) | CMA1GSK3AGSK3BTNFCXCR4 | |
| SCHEMBL13792755 | 0.86 | CMA1 (0.44) | CMA1GSK3AGSK3BCXCR4ALDH1A1 | |
| SCHEMBL13792788 | 0.86 | CMA1 (0.44) | CMA1GSK3AGSK3BSMN1; SMN2CXCR4 | |
| SCHEMBL13792166 | 0.85 | ALDH1A1 (0.45) | CMA1GSK3AGSK3BCXCR4ALDH1A1 | |
| SCHEMBL13793023 | 0.84 | KCNA5 (0.43) | CMA1GSK3AGSK3BSMN1; SMN2CXCR4 | |
| SCHEMBL13792818 | 0.84 | TP53 (0.53) | CMA1CXCR4TP53ALDH1A1MEN1 | |
| SCHEMBL13792825 | 0.84 | HSP90AA1 (0.42) | CMA1GSK3AGSK3BCXCR4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7544812-B2 | For example, 2-(4-{2-[1-(4-tert-Butyl-benzyl)-3-methyl-2-oxo-imidazolidin-4-yl]-ethoxy}-2-methyl-phenoxy)-2-methyl-propionic acid, 2-(4-{3-[1-(4-tert-Butyl-benzyl)-3-methyl-2-oxo-imidazolidin-4-yl]-propyl}-2-methyl-phenoky)-2-methyl-propionic acid; for treating diabetes mellitus | ELI LILLY AND COMPANY (US) | 2009-06-09 | — | — | US | disclosed |
| US-7544812-B2 | For example, 2-(4-{2-[1-(4-tert-Butyl-benzyl)-3-methyl-2-oxo-imidazolidin-4-yl]-ethoxy}-2-methyl-phenoxy)-2-methyl-propionic acid, 2-(4-{3-[1-(4-tert-Butyl-benzyl)-3-methyl-2-oxo-imidazolidin-4-yl]-propyl}-2-methyl-phenoky)-2-methyl-propionic acid; for treating diabetes mellitus | ELI LILLY AND COMPANY (US) | 2009-06-09 | — | — | US | disclosed |