Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 20/20 | 0.67 |
| ▸ | GABRB3 | P28472 | 20/20 | 0.67 |
| ▸ | GABRA5 | P31644 | 20/20 | 0.67 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.53 |
| ▸ | GABRA3 | P34903 | 5/20 | 0.53 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2403395 | 0.82 | GABRG2 (0.71) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL4593483 | 0.80 | GABRG2 (1.00) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL2402138 | 0.80 | GABRG2 (1.00) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL1375888 | 0.78 | GABRG2 (1.00) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL3872397 | 0.76 | GABRG2 (0.74) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL5186663 | 0.75 | GABRG2 (0.78) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL2426679 | 0.75 | GABRG2 (0.73) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL2433473 | 0.73 | GABRG2 (0.69) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL3923777 | 0.72 | GABRG2 (0.72) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL3924664 | 0.72 | GABRG2 (0.79) | GABRG2GABRB3GABRA5GABRA1GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4751398-B2 | — | — | 2011-08-17 | — | — | JP | claimed |
| EP-1807432-A1 | HALOGEN SUBSTITUTED BENZODIAZEPINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2007-07-18 | — | — | EP | claimed |
| WO-2006045429-A1 | HALOGEN SUBSTITUTED BENZODIAZEPINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-05-04 | — | — | WO | claimed |
| EP-1807432-A1 | HALOGEN SUBSTITUTED BENZODIAZEPINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006045429-A1 | HALOGEN SUBSTITUTED BENZODIAZEPINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-05-04 | — | — | WO | disclosed |