Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 3/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.55 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.41 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.41 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3118253 | 0.88 | KCNA5 (0.69) | KCNA5KCNH2DPP4MAPK8ALDH1A1 | |
| SCHEMBL1376904 | 0.86 | KCNA5 (0.59) | KCNA5KCNH2DPP4LMNAMAPK8 | |
| SCHEMBL1377892 | 0.85 | KCNA5 (0.50) | KCNA5KCNH2MAOBDPP4MAPK8 | |
| SCHEMBL3621163 | 0.83 | KCNA5 (0.58) | KCNA5KCNH2MAOBALDH1A1MAPK13 | |
| SCHEMBL1463978 | 0.75 | KCNH2 (0.60) | KCNH2MAOBALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL1463771 | 0.75 | KCNH2 (0.60) | KCNH2LMNAALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL3094005 | 0.75 | KCNA5 (0.63) | KCNA5KCNH2DPP4MAPK8ALDH1A1 | |
| SCHEMBL15263687 | 0.75 | BRD4 (0.58) | MAOB | |
| SCHEMBL4690913 | 0.75 | KCNA5 (0.66) | KCNA5KCNH2DPP4MAPK8ALDH1A1 | |
| SCHEMBL13499834 | 0.74 | MAPK14 (0.49) | MAOBLMNAALDH1A1MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1667982-B1 | ISOQUINOLINONE POTASSIUM CHANNEL INHIBITORS | MERCK SHARP & DOHME (US) | 2013-07-31 | — | — | EP | claimed |
| US-8338449-B2 | Isoquinolinone potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2012-12-25 | — | — | US | claimed |
| JP-4718467-B2 | — | — | 2011-07-06 | — | — | JP | claimed |
| US-20100256698-A1 | Isoquinolinone Potassium Channel Inhibitors | MERCK & CO., INC. (US) | 2010-10-07 | — | — | US | claimed |
| EP-1667982-A4 | ISOQUINOLINONE POTASSIUM CHANNEL INHIBITORS | MERCK & CO INC (US) | 2008-08-13 | — | — | EP | claimed |
| US-20070027177-A1 | Isoquinolinone potassium channel inhibitors | MERCK SHARP & DOHME CORP. | 2007-02-01 | — | — | US | claimed |
| EP-1667982-A2 | ISOQUINOLINONE POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2006-06-14 | — | — | EP | claimed |
| WO-2005030791-A2 | ISOQUINOLINONE POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2005-04-07 | — | — | WO | claimed |
| EP-1667982-B1 | ISOQUINOLINONE POTASSIUM CHANNEL INHIBITORS | MERCK SHARP & DOHME (US) | 2013-07-31 | — | — | EP | disclosed |
| US-8338449-B2 | Isoquinolinone potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2012-12-25 | — | — | US | disclosed |
| US-8338449-B2 | Isoquinolinone potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2012-12-25 | — | — | US | disclosed |
| US-8338449-B2 | Isoquinolinone potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2012-12-25 | — | — | US | disclosed |
| US-20100256698-A1 | Isoquinolinone Potassium Channel Inhibitors | MERCK & CO., INC. (US) | 2010-10-07 | — | — | US | disclosed |
| US-20100256698-A1 | Isoquinolinone Potassium Channel Inhibitors | MERCK & CO., INC. (US) | 2010-10-07 | — | — | US | disclosed |
| EP-1667982-A4 | ISOQUINOLINONE POTASSIUM CHANNEL INHIBITORS | MERCK & CO INC (US) | 2008-08-13 | — | — | EP | disclosed |
| US-20070027177-A1 | Isoquinolinone potassium channel inhibitors | MERCK SHARP & DOHME CORP. | 2007-02-01 | — | — | US | disclosed |
| US-20070027177-A1 | Isoquinolinone potassium channel inhibitors | MERCK SHARP & DOHME CORP. | 2007-02-01 | — | — | US | disclosed |
| US-20070027177-A1 | Isoquinolinone potassium channel inhibitors | MERCK SHARP & DOHME CORP. | 2007-02-01 | — | — | US | disclosed |
| EP-1667982-A2 | ISOQUINOLINONE POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2006-06-14 | — | — | EP | disclosed |
| WO-2005030791-A2 | ISOQUINOLINONE POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2005-04-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070027177-A1 | Isoquinolinone potassium channel inhibitors | KCNJ2, KCNQ1, KCNQ2 | KCNA5 23/4885KCNH2 4/4885MAOB 3272/4885 |
| US-20100256698-A1 | Isoquinolinone Potassium Channel Inhibitors | KCNJ2, KCNQ1, KCNQ2 | KCNA5 26/4885KCNH2 5/4885MAOB 3641/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.