Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 9/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | MGLL | Q99685 | 3/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4487783 | 0.92 | HPGD (0.56) | HPGDALDH1A1RAB9ANPC1MGLL | |
| SCHEMBL1381949 | 0.87 | KMT2A (0.61) | HPGDALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL1378425 | 0.82 | KMT2A (0.58) | HPGDALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL4495287 | 0.82 | HPGD (0.55) | HPGDALDH1A1RAB9ANPC1MGLL | |
| SCHEMBL1380499 | 0.81 | NTRK1 (0.55) | HPGDALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL4513274 | 0.81 | HPGD (0.64) | HPGDALDH1A1RAB9ANPC1MGLL | |
| SCHEMBL1378814 | 0.79 | L3MBTL1 (0.58) | HPGDALDH1A1RAB9AMEN1KMT2A | |
| SCHEMBL1378210 | 0.79 | HPGD (0.61) | HPGDALDH1A1RAB9ANPC1MGLL | |
| SCHEMBL1377927 | 0.78 | MEN1 (0.55) | HPGDALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL1380975 | 0.78 | HPGD (0.74) | HPGDALDH1A1MEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4769720-B2 | — | — | 2011-09-07 | — | — | JP | claimed |
| EP-1664021-A1 | N-SUBSTITUTED BENZIMIDAZOLYL C-KIT INHIBITORS | OSI Pharmaceuticals, Inc. (US) | 2006-06-07 | — | — | EP | claimed |
| WO-2005021531-A1 | N-SUBSTITUTED BENZIMIDAZOLYL C-KIT INHIBITORS | OSI PHARMACEUTICALS, INC. (US) | 2005-03-10 | — | — | WO | claimed |