Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LYN | P07948 | 2/20 | 0.62 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.62 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.54 |
| ▸ | GSK3A | P49840 | 5/20 | 0.41 |
| ▸ | SRC | P12931 | 4/20 | 0.41 |
| ▸ | SYK | P43405 | 4/20 | 0.41 |
| ▸ | BRAF | P15056 | 9/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.39 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13359165 | 0.88 | LYN (0.79) | LYNMAPK9MAPK14BRAF | |
| SCHEMBL13798012 | 0.86 | LYN (0.60) | LYNMAPK9MAPK14GSK3ASRC | |
| SCHEMBL13797964 | 0.84 | LYN (0.82) | LYNMAPK9MAPK14BRAF | |
| SCHEMBL13797968 | 0.80 | MAPK14 (0.69) | LYNMAPK9MAPK14GSK3ASRC | |
| SCHEMBL13797943 | 0.79 | MAPK14 (0.72) | LYNMAPK9MAPK14BRAF | |
| SCHEMBL13797938 | 0.78 | MAPK14 (0.73) | LYNMAPK9MAPK14BRAF | |
| SCHEMBL13797996 | 0.78 | MAPK14 (0.69) | LYNMAPK9MAPK14BRAF | |
| SCHEMBL13797952 | 0.78 | MAPK14 (0.72) | LYNMAPK9MAPK14GSK3ABRAF | |
| SCHEMBL13798007 | 0.77 | LYN (0.71) | LYNMAPK9MAPK14BRAF | |
| SCHEMBL13797953 | 0.77 | LYN (0.71) | LYNMAPK9MAPK14BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7550461-B2 | Benzofuran and benzothiophene compounds useful in treating cytokine mediated diseases | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-06-23 | — | — | US | disclosed |
| US-7550461-B2 | Benzofuran and benzothiophene compounds useful in treating cytokine mediated diseases | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-06-23 | — | — | US | disclosed |