Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 2/20 | 0.37 |
| ▸ | TYK2 | P29597 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13798616 | 0.92 | CYP2C9 (0.43) | CYP2C9CYP2C19JAK1TYK2JAK2 | |
| SCHEMBL3838917 | 0.89 | CYP2C9 (0.56) | CYP2C9CYP2C19MEN1KMT2AKDM4E | |
| SCHEMBL11947247 | 0.86 | CYP2C9 (0.39) | CYP2C9CYP2C19MAPTRAB9AABCC3 | |
| SCHEMBL13798659 | 0.84 | CYP2C9 (0.38) | CYP2C9CYP2C19JAK1TYK2JAK2 | |
| SCHEMBL10254255 | 0.83 | MAPK14 (0.38) | CYP2C9CYP2C19JAK1TYK2JAK2 | |
| SCHEMBL4104237 | 0.82 | YTHDC1 (0.43) | CYP2C9CYP2C19MEN1KMT2ACCNE1 | |
| SCHEMBL10256174 | 0.82 | ADORA1 (0.37) | CYP2C9CYP2C19JAK1TYK2JAK2 | |
| SCHEMBL4110938 | 0.82 | CYP2C9 (0.55) | CYP2C9CYP2C19JAK1TYK2JAK2 | |
| SCHEMBL13561273 | 0.82 | CYP2C9 (0.55) | CYP2C9CYP2C19JAK1TYK2JAK2 | |
| SCHEMBL11946762 | 0.79 | CYP2C9 (0.43) | CYP2C9CYP2C19JAK3RORCCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009079412-A2 | REVERSE TRANSCRIPTASE INHIBITORS | ARDEA BIOSCIENCES INC. (US) | 2009-06-25 | — | — | WO | disclosed |