Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 14/20 | 0.67 |
| ▸ | ROCK1 | Q13464 | 9/20 | 0.67 |
| ▸ | CDC42BPA | Q5VT25 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1986250 | 0.90 | ROCK2 (0.76) | ROCK2ROCK1CDC42BPALMNATP53 | |
| SCHEMBL12562593 | 0.85 | ROCK2 (0.64) | ROCK2ROCK1CDC42BPALMNATP53 | |
| SCHEMBL12562384 | 0.80 | ROCK2 (1.00) | ROCK2ROCK1CDC42BPA | |
| SCHEMBL12562389 | 0.79 | ROCK2 (0.76) | ROCK2ROCK1CDC42BPALMNATP53 | |
| SCHEMBL1990202 | 0.79 | ROCK2 (0.77) | ROCK2ROCK1CDC42BPA | |
| SCHEMBL1987125 | 0.78 | ROCK2 (0.68) | ROCK2ROCK1CDC42BPALMNATP53 | |
| SCHEMBL1987128 | 0.77 | ROCK2 (0.60) | ROCK2ROCK1CDC42BPALMNATP53 | |
| SCHEMBL12562597 | 0.75 | ROCK2 (0.75) | ROCK2ROCK1CDC42BPA | |
| SCHEMBL13457023 | 0.75 | ROCK2 (0.65) | ROCK2ROCK1CDC42BPALMNATP53 | |
| SCHEMBL1987998 | 0.74 | ROCK2 (0.67) | ROCK2ROCK1CDC42BPA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009079008-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | FENG YANGBO (US) | 2009-06-25 | — | — | WO | disclosed |