Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 10/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.42 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KLK7 | P49862 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15014675 | 0.91 | KCNA5 (0.44) | KCNA5KCNH2LMNA | |
| SCHEMBL3889488 | 0.87 | KCNA5 (0.52) | KCNA5KCNH2LMNA | |
| SCHEMBL3823590 | 0.87 | KCNA5 (0.54) | KCNA5KCNH2LMNA | |
| SCHEMBL4143386 | 0.81 | GPR119 (0.47) | GPR119UCHL1 | |
| SCHEMBL3442475 | 0.78 | GPR119 (0.47) | GPR119UCHL1LMNA | |
| SCHEMBL21713147 | 0.77 | KLK7 (0.46) | GPR119UCHL1LMNAKLK7 | |
| SCHEMBL20400353 | 0.77 | KLK7 (0.46) | GPR119UCHL1LMNAKLK7 | |
| SCHEMBL1843454 | 0.76 | KLK7 (0.45) | GPR119UCHL1LMNAKLK7 | |
| SCHEMBL13997813 | 0.76 | KLK7 (0.45) | GPR119UCHL1LMNAKLK7 | |
| SCHEMBL29997863 | 0.76 | KLK7 (0.45) | GPR119UCHL1LMNAKLK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1776355-B1 | POTASSIUM CHANNEL INHIBITORS | MERCK SHARP & DOHME (US) | 2013-06-12 | — | — | EP | claimed |
| JP-4719744-B2 | — | — | 2011-07-06 | — | — | JP | claimed |
| EP-1776355-A4 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO INC (US) | 2009-08-12 | — | — | EP | claimed |
| EP-1776355-A2 | POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2007-04-25 | — | — | EP | claimed |
| WO-2006014877-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2006-02-09 | — | — | WO | claimed |
| US-7569589-B2 | Potassium channel inhibitors | MERCK & CO., INC. (US) | 2009-08-04 | — | — | US | disclosed |
| US-7569589-B2 | Potassium channel inhibitors | MERCK & CO., INC. (US) | 2009-08-04 | — | — | US | disclosed |