Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 7/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.39 |
| ▸ | F10 | P00742 | 2/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.36 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.35 |
| ▸ | UBE2M | P61081 | 1/20 | 0.34 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1240763 | 0.89 | F10 (0.40) | CYP3A4F10CYP11B2CYP11B1MCOLN3 | |
| SCHEMBL1243596 | 0.73 | KCNA5 (0.41) | CYP3A4CACNA1BNR1I2CYP11B2CYP11B1 | |
| SCHEMBL1376017 | 0.73 | BCHE (0.48) | — | |
| SCHEMBL3819011 | 0.66 | HSD11B1 (0.39) | CYP3A4CYP11B2CYP11B1 | |
| SCHEMBL1240757 | 0.64 | KCNA5 (0.42) | CYP3A4F10 | |
| SCHEMBL1243595 | 0.64 | CYP3A4 (0.44) | CYP3A4MCOLN3 | |
| SCHEMBL3818100 | 0.63 | CLK4 (0.36) | CYP3A4CYP11B2CYP11B1 | |
| SCHEMBL4198056 | 0.62 | CYP3A4 (0.36) | CYP3A4CYP11B2CYP11B1 | |
| SCHEMBL4283363 | 0.62 | CACNA1B (0.63) | CYP3A4CACNA1BNR1I2UBE2MDCUN1D1 | |
| SCHEMBL1378033 | 0.62 | KCNA5 (0.43) | CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4719745-B2 | — | — | 2011-07-06 | — | — | JP | claimed |
| EP-1781635-A4 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO INC (US) | 2009-02-25 | — | — | EP | claimed |
| EP-1781635-A2 | POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2007-05-09 | — | — | EP | claimed |
| WO-2006015159-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2006-02-09 | — | — | WO | claimed |