Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 1/20 | 0.37 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30482175 | 0.86 | PDE2A (0.50) | AVPR2GPR27PDE2AKDM4EALDH1A1 | |
| SCHEMBL6495907 | 0.86 | PDE2A (0.50) | AVPR2GPR27PDE2AKDM4EALDH1A1 | |
| SCHEMBL11342078 | 0.80 | CYP2C19 (0.49) | KDM4EALDH1A1HPGDHSD17B10CYP2C19 | |
| SCHEMBL22407104 | 0.73 | TLR8 (0.44) | KDM4EALDH1A1HPGDHSD17B10USP2 | |
| SCHEMBL30231714 | 0.72 | HPGD (0.53) | KDM4EALDH1A1HPGDCES2 | |
| SCHEMBL473969 | 0.72 | HPGD (0.53) | KDM4EALDH1A1HPGDCES2 | |
| SCHEMBL30740081 | 0.71 | JAK2 (0.57) | PDE2AKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL1199588 | 0.71 | JAK2 (0.57) | PDE2AKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL322161 | 0.71 | TSHR (0.65) | KDM4EALDH1A1USP2JAK2JAK1 | |
| SCHEMBL29384783 | 0.71 | TSHR (0.65) | KDM4EALDH1A1USP2JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7544702-B2 | Bisaryl-sulfonamides | AMGEN INC. (US) | 2009-06-09 | — | — | US | disclosed |