Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 2/20 | 0.50 |
| ▸ | CES2 | O00748 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.47 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | TYK2 | P29597 | 1/20 | 0.47 |
| ▸ | CFTR | P13569 | 1/20 | 0.46 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
| ▸ | SMO | Q99835 | 1/20 | 0.44 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30482175 | 1.00 | PDE2A (0.50) | PDE2ACES2KDM4EALDH1A1HPGD | |
| SCHEMBL13801463 | 0.86 | AVPR2 (0.37) | PDE2ACES2KDM4EALDH1A1HPGD | |
| SCHEMBL30740081 | 0.85 | JAK2 (0.57) | PDE2ACES2KDM4EALDH1A1HPGD | |
| SCHEMBL1199588 | 0.85 | JAK2 (0.57) | PDE2ACES2KDM4EALDH1A1HPGD | |
| SCHEMBL1818435 | 0.83 | KDM4E (0.62) | PDE2ACES2KDM4EALDH1A1HPGD | |
| SCHEMBL11342078 | 0.83 | CYP2C19 (0.49) | KDM4EALDH1A1HPGDHSD17B10CYP2C19 | |
| SCHEMBL1455625 | 0.83 | CES2 (0.52) | PDE2ACES2KDM4EALDH1A1HPGD | |
| SCHEMBL22407104 | 0.82 | TLR8 (0.44) | KDM4EALDH1A1HPGDHSD17B10USP2 | |
| SCHEMBL21852902 | 0.82 | CES2 (0.55) | CES2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL8493470 | 0.82 | ALDH1A1 (0.48) | PDE2ACES2KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0365914-B1 | FLUORINE-CONTAINING ACETOPHENONES OPTIONALLY HALOGENATED IN THE CH3-GROUP, AND THEIR PREPARATION FROM FLUORINATED BENZONITRILES | BAYER AG (DE) | 1992-07-22 | — | — | EP | claimed |
| US-20250136594-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. | 2025-05-01 | — | — | US | disclosed |
| WO-2023146987-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |
| WO-2023146987-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |
| US-20220098159-A1 | CARBAMATE DERIVATIVES AND USES THEREOF | NodThera Limited (GB) | 2022-03-31 | — | — | US | disclosed |
| US-10981894-B2 | Melanocortin subtype-2 receptor (MC2R) antagonists and uses thereof | Crinetics Pharmaceuticals, Inc. (US) | 2021-04-20 | — | — | US | disclosed |
| WO-2020152361-A1 | CARBAMATE DERIVATIVES AND USES THEREOF | NodThera Limited (GB) | 2020-07-30 | — | — | WO | disclosed |
| US-7544702-B2 | Bisaryl-sulfonamides | AMGEN INC. (US) | 2009-06-09 | — | — | US | disclosed |
| US-20050171363-A1 | Process for producing trifluoromethyl- substituted 2- alkoxyacetophenone derivatives | CENTRAL GLASS COMPANY, LIMITED (JP) | 2005-08-04 | — | — | US | disclosed |
| US-6706748-B2 | USE AS MICROBICIDES | NIHON BAYER AGROCHEM, K.K. (JP) | 2004-03-16 | — | — | US | disclosed |
| US-6093851-A | N-(α-alkylbenzylidene)-α-phenylalkylamine, its use and process for producing the same and process for producing intermediate therefor | SUMITOMO CHEMICAL COMPANY, LTD. (JP) | 2000-07-25 | — | — | US | disclosed |
| EP-0735018-B1 | N-(alpha-alkylbenzylidene)-alpha-phenylalkylamine, its use and process for producing the same and process for producing intermediate therefor | SUMITOMO CHEMICAL CO (JP) | 1999-07-21 | — | — | EP | disclosed |
| US-5739401-A | N-(α-alkylbenzylidene)-α-phenylalkylamine, its use and process for producing the same and process for producing intermediate therefor | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1998-04-14 | — | — | US | disclosed |
| EP-0735018-A1 | N-(alpha-alkylbenzylidene)-alpha-phenylalkylamine, its use and process for producing the same and process for producing intermediate therefor | SUMITOMO CHEMICAL COMPANY LIMITED (JP) | 1996-10-02 | — | — | EP | disclosed |
| EP-0365913-B1 | Substituted 2-aminothiazoles | BAYER AG (DE) | 1993-11-18 | — | — | EP | disclosed |
| US-5142092-A | Chemical intermediate for making fungicides | BAYER AKTIENGESELLSCHAFT (DE) | 1992-08-25 | — | — | US | disclosed |
| EP-0365914-B1 | FLUORINE-CONTAINING ACETOPHENONES OPTIONALLY HALOGENATED IN THE CH3-GROUP, AND THEIR PREPARATION FROM FLUORINATED BENZONITRILES | BAYER AG (DE) | 1992-07-22 | — | — | EP | disclosed |
| US-5104879-A | ANTIMYCOTICALLY ACTIVE SUBSTITUTED 2-AMINOTHIAZOLES | BAYER AKTIENGESELLSCHAFT (DE) | 1992-04-14 | — | — | US | disclosed |
| EP-0365914-A2 | Fluorine-containing acetophenones optionally halogenated in the CH3-group, and their preparation from fluorinated benzonitriles | BAYER AG (DE) | 1990-05-02 | — | — | EP | disclosed |
| EP-0365913-A2 | Substituted 2-aminothiazoles | BAYER AG (DE) | 1990-05-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250136594-A1 | COMPOUNDS AND METHODS OF USE | CNKSR1, UGT1A1, REV1 | PDE2A 333/4885CES2 1111/4885KDM4E 1639/4885 |
| US-20220098159-A1 | CARBAMATE DERIVATIVES AND USES THEREOF | CASP1, IL1B, PYCARD | PDE2A 900/4885CES2 2133/4885KDM4E 1074/4885 |
| US-20050171363-A1 | Process for producing trifluoromethyl- substituted 2- alkoxyacetophenone derivatives | HACL2, BOLA2; BOLA2B, ADH5 | PDE2A 3298/4885CES2 148/4885KDM4E 881/4885 |
| US-10981894-B2 | Melanocortin subtype-2 receptor (MC2R) antagonists and uses thereof | MC3R, MC1R, MC2R | PDE2A 1206/4885CES2 2446/4885KDM4E 4387/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.