Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 4/20 | 0.39 |
| ▸ | TUBB | P07437 | 4/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 4/20 | 0.39 |
| ▸ | TUBA1B | P68363 | 4/20 | 0.39 |
| ▸ | TUBA4A | P68366 | 4/20 | 0.39 |
| ▸ | TUBB4B | P68371 | 4/20 | 0.39 |
| ▸ | TUBB3 | Q13509 | 4/20 | 0.39 |
| ▸ | TUBB2A | Q13885 | 4/20 | 0.39 |
| ▸ | TUBB8 | Q3ZCM7 | 4/20 | 0.39 |
| ▸ | TUBA3E | Q6PEY2 | 4/20 | 0.39 |
| ▸ | TUBA1A | Q71U36 | 4/20 | 0.39 |
| ▸ | TUBA1C | Q9BQE3 | 4/20 | 0.39 |
| ▸ | TUBB6 | Q9BUF5 | 4/20 | 0.39 |
| ▸ | TUBB2B | Q9BVA1 | 4/20 | 0.39 |
| ▸ | TUBB1 | Q9H4B7 | 4/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3903263 | 0.85 | CYP2A6 (0.54) | BACE1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL3912118 | 0.82 | CLK1 (0.40) | BACE1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL3912125 | 0.82 | CLK1 (0.40) | BACE1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL13790852 | 0.79 | FDPS (0.40) | BACE1CA2CLK1LMNACYP3A4 | |
| SCHEMBL13791095 | 0.78 | BACE1 (0.44) | BACE1PDE3BPDE3ACA2CLK1 | |
| SCHEMBL13790850 | 0.76 | BACE1 (0.45) | BACE1CYP2A6PDE3BPDE3ACA2 | |
| SCHEMBL3905190 | 0.75 | CYP2A6 (0.47) | BACE1CYP2A6PDE3BPDE3ACA2 | |
| SCHEMBL13802155 | 0.73 | BACE1 (0.43) | BACE1CYP2A6PDE3BPDE3ACA2 | |
| SCHEMBL3911211 | 0.71 | BACE1 (0.41) | BACE1CYP2A6PDE3BPDE3ACA2 | |
| SCHEMBL13791184 | 0.70 | BACE1 (0.40) | BACE1PDE3BPDE3ACA2CLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7553867-B2 | Furan or thiophene derivative and medicinal use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-06-30 | — | — | US | disclosed |