Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.53 |
| ▸ | SCN9A | Q15858 | 12/20 | 0.49 |
| ▸ | ACP1 | P24666 | 2/20 | 0.48 |
| ▸ | SCN7A | Q01118 | 6/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.47 |
| ▸ | SCN10A | Q9Y5Y9 | 3/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.45 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.45 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.45 |
| ▸ | PDE2A | O00408 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1381216 | 0.93 | HRH3 (0.61) | HRH3SCN9AACP1SCN7AKCNH2 | |
| SCHEMBL1377869 | 0.93 | HRH3 (0.61) | HRH3SCN9ASCN7AKCNH2SCN10A | |
| SCHEMBL1380830 | 0.90 | HRH3 (0.67) | HRH3SCN9ASCN7AKCNH2SCN10A | |
| SCHEMBL1378414 | 0.89 | SCN9A (0.53) | HRH3SCN9ASCN7AKCNH2SCN10A | |
| SCHEMBL5178917 | 0.89 | HRH3 (0.51) | HRH3SCN9ASCN7AKCNH2SCN10A | |
| SCHEMBL1381575 | 0.88 | HRH3 (0.56) | HRH3SCN9ASCN7AKCNH2SCN10A | |
| SCHEMBL1378505 | 0.88 | HRH3 (0.51) | HRH3SCN9ASCN7AKCNH2SCN10A | |
| SCHEMBL1378338 | 0.86 | HRH3 (0.49) | HRH3SCN9ASCN7AKCNH2SCN10A | |
| SCHEMBL2208858 | 0.84 | HRH3 (0.44) | HRH3SCN9AACP1SCN7AKCNH2 | |
| SCHEMBL1380750 | 0.84 | HRH3 (0.50) | HRH3SCN9ASCN7AKCNH2SCN10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4660553-B2 | — | — | 2011-03-30 | — | — | JP | claimed |
| JP-2008517003-A | — | — | 2008-05-22 | — | — | JP | claimed |
| EP-1805166-A1 | QUINOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2007-07-11 | — | — | EP | claimed |
| WO-2006045416-A1 | QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-05-04 | — | — | WO | claimed |