Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.51 |
| ▸ | SCN9A | Q15858 | 16/20 | 0.46 |
| ▸ | SCN7A | Q01118 | 7/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.45 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.41 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.41 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1378338 | 0.94 | HRH3 (0.49) | HRH3SCN9ASCN7AKCNH2SCN10A | |
| SCHEMBL1381216 | 0.92 | HRH3 (0.61) | HRH3SCN9ASCN7AKCNH2SCN10A | |
| SCHEMBL1377869 | 0.92 | HRH3 (0.61) | HRH3SCN9ASCN7AKCNH2SCN10A | |
| SCHEMBL1380830 | 0.89 | HRH3 (0.67) | HRH3SCN9ASCN7AKCNH2SCN10A | |
| SCHEMBL1380359 | 0.89 | HRH3 (0.53) | HRH3SCN9ASCN7AKCNH2SCN10A | |
| SCHEMBL1378414 | 0.88 | SCN9A (0.53) | HRH3SCN9ASCN7AKCNH2SCN10A | |
| SCHEMBL1378505 | 0.87 | HRH3 (0.51) | HRH3SCN9ASCN7AKCNH2SCN10A | |
| SCHEMBL1381575 | 0.87 | HRH3 (0.56) | HRH3SCN9ASCN7AKCNH2SCN10A | |
| SCHEMBL2208858 | 0.87 | HRH3 (0.44) | HRH3SCN9ASCN7AKCNH2 | |
| SCHEMBL1380750 | 0.84 | HRH3 (0.50) | HRH3SCN9ASCN7AKCNH2SCN10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1805166-A1 | QUINOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006045416-A1 | QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-05-04 | — | — | WO | disclosed |