Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAA2 | P54646 | 18/20 | 0.48 |
| ▸ | PRKAB2 | O43741 | 6/20 | 0.48 |
| ▸ | PRKAG1 | P54619 | 6/20 | 0.48 |
| ▸ | PRKAA1 | Q13131 | 6/20 | 0.48 |
| ▸ | PRKAG3 | Q9UGI9 | 6/20 | 0.48 |
| ▸ | PRKAG2 | Q9UGJ0 | 6/20 | 0.48 |
| ▸ | PRKAB1 | Q9Y478 | 6/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL61677 | 0.91 | PRKAA2 (0.57) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL62194 | 0.85 | DRD4 (0.56) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL91078 | 0.83 | PRKAA2 (0.59) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL5020461 | 0.83 | PRKAA2 (0.59) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL61881 | 0.81 | SLC6A5 (0.58) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL91109 | 0.81 | DRD4 (0.52) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL3666114 | 0.81 | PRKAA2 (0.47) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL649210 | 0.79 | PRKAA2 (0.67) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL2509533 | 0.79 | PRKAA2 (0.50) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL2503938 | 0.79 | PRKAA2 (0.50) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009076631-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-06-18 | — | — | WO | disclosed |