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Sugi Predict / Targets / SLC6A5

SLC6A5

Sodium- and chloride-dependent glycine transporter 2 · Q9Y345 · SLC6A5 on Sugi Atlas →

54,000 patent compounds predicted against SLC6A5, 35,753 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL254664 SCHEMBL254664 0.51 18/20
SCHEMBL146674 SCHEMBL146674 0.50 10/20
SCHEMBL116949 SCHEMBL116949 0.55 9/20
SCHEMBL69676 SCHEMBL69676 0.45 9/20
SCHEMBL61321 SCHEMBL61321 0.52 8/20
SCHEMBL61238 SCHEMBL61238 0.49 8/20
SCHEMBL60972 SCHEMBL60972 0.46 8/20
SCHEMBL62194 SCHEMBL62194 0.54 6/20
SCHEMBL318959 SCHEMBL318959 0.53 6/20
SCHEMBL117372 SCHEMBL117372 0.53 6/20
SCHEMBL280991 SCHEMBL280991 0.42 6/20
SCHEMBL148315 SCHEMBL148315 0.41 6/20
SCHEMBL91109 SCHEMBL91109 0.52 5/20
SCHEMBL61089 SCHEMBL61089 0.45 5/20
SCHEMBL319470 SCHEMBL319470 0.55 4/20
SCHEMBL318445 SCHEMBL318445 0.52 4/20
SCHEMBL264943 SCHEMBL264943 0.51 4/20
SCHEMBL62395 SCHEMBL62395 0.49 4/20
SCHEMBL61952 SCHEMBL61952 0.46 4/20
SCHEMBL210786 SCHEMBL210786 0.60 3/20

Clinical trials — most relevant to SLC6A5 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Forebrain Electroneutral Transporters in Salt-sensitive Hypertension: an MRI Study PHASE4RECRUITING
Febuxostat, Blood Pressure and the Intrarenal Renin-Angiotensin System (RAS) PHASE4COMPLETED
L-arginine Treatment in Mild Hypertension PHASE4UNKNOWN
Pharmacogenetic Treatment With Anti-Glutaminergic Agents for Comorbid PTSD & AUD PHASE3COMPLETED
First-in-Human Evaluation of an Astrocytic Glutamate Transporter (EAAT2) PET Tracer in Dementia PHASE1/PHASE2RECRUITING
D-amino Acid Oxidase Inhibition (DAAOI-1) add-on Treatment for Chronic Schizophrenia PHASE2COMPLETED
Effect of Sarcosine on Symptomatology, Quality of Life, Oxidative Stress and Glutamatergic Parameters in Schizophrenia PHASE2COMPLETED
GlyT-1 Inhibitor Treatment for Refractory Schizophrenia PHASE2COMPLETED
DAAOI-1 Treatment for Treatment-resistant Schizophrenia PHASE2COMPLETED
Neurobiology of a Mutation in Glycine Metabolism in Psychotic Disorders PHASE2COMPLETED
Evaluating Safe Ketone Thresholds To Minimise Ketosis in People With Type 1 Diabetes Using Dapagliflozin PHASE2NOT_YET_RECRUITING
N-acetylcysteine (NAC) for Improving Cognitive Dysfunction in Schizophrenia PHASE1COMPLETED
Effect of, OAT3, on the Renal Secretion of Cefotaxime PHASE1COMPLETED
Mechanism and Effects of Manipulating Chloride Homeostasis in Stable Heart Failure EARLY_PHASE1COMPLETED
Pharmacokinetic Drug-Drug Interaction Study to Identify Biomarkers of Kidney Transporters EARLY_PHASE1COMPLETED
POTASSIUM-RICH SALT SUBSTITUTES IN KIDNEY TRANSPLANT RECIPIENTS nanNOT_YET_RECRUITING
Lithium Countertransport and Blood Pressure In CARDIA and TOMHS nanCOMPLETED
Natural History Study of SLC25A46 Mutation-related Mitochondriopathy nanCOMPLETED
Effects of Sulfasalazine on BOLD Response to Alcohol Cues nanCOMPLETED
Oxalate and Citrate in Humans - Response to Citrate nanRECRUITING
Acute Glycine Pharmacodynamic Study nanCOMPLETED
Stem Cell Study of Genetics and Drug Addiction nanCOMPLETED
Renal Transporters After Renal Transplantation nanUNKNOWN
Insulin Detemir in Obesity Management nanACTIVE_NOT_RECRUITING
CRF vs WCRF or PRF-DRG in CLBP of FJ Origin and RFA Failure of MBDR: Central Sensitization and Aberrant Nerve Sprouting nanUNKNOWN
Childhood Adversity, Genetic Polymorphisms and Stress in First Onset Major Depression nanCOMPLETED
SLC13A5 Deficiency Natural History Study - United States Only nanENROLLING_BY_INVITATION
Sodium Transport: Genetics and Hypertension nanCOMPLETED
Evaluation of Renal Function in Patients With Hyperthyroidism nanNOT_YET_RECRUITING
A Study of Cases with Abnormal Serum Ammonia in Neonate and Children Attending Assiut University Children Hospital nanNOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a SLC6A5 binder may also engage these)

ProteinNameSimilarity
Q761V0 — 1.000 Q761V0 →
P58295 — 0.999 P58295 →
A7Y2X0 — 0.993 A7Y2X0 →
SLC6A4 Sodium-dependent serotonin transporter 0.991 landscape →
SLC6A9 Sodium- and chloride-dependent glycine transporter 1 0.990 landscape →
O88575 — 0.990 O88575 →
Q9H1V8 — 0.989 Q9H1V8 →
P28571 — 0.989 P28571 →
Q61327 — 0.989 Q61327 →
Q9XS59 — 0.989 Q9XS59 →
P23977 — 0.989 P23977 →
Q9MYX0 — 0.989 Q9MYX0 →
Q8BG16 — 0.989 Q8BG16 →
P27922 — 0.989 P27922 →
Q08469 — 0.988 Q08469 →
P31652 — 0.987 P31652 →
P31662 — 0.987 P31662 →
Q9VR07 — 0.987 Q9VR07 →
O18875 — 0.987 O18875 →
Q8BJI1 — 0.987 Q8BJI1 →
P31649 — 0.986 P31649 →
SLC6A19 Sodium-dependent neutral amino acid transporter B(0)AT1 0.986 landscape →
SLC6A11 Sodium- and chloride-dependent GABA transporter 3 0.986 landscape →
Q9GJT6 — 0.985 Q9GJT6 →
Q96N87 — 0.985 Q96N87 →
P48029 — 0.985 P48029 →
P31651 — 0.985 P31651 →
SLC6A3 Sodium-dependent dopamine transporter 0.985 landscape →
Q9XT49 — 0.985 Q9XT49 →
Q9UN76 — 0.985 Q9UN76 →