Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 4/20 | 0.51 |
| ▸ | RORC | P51449 | 1/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | TERT | O14746 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 2/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14495293 | 1.00 | PDE4B (0.51) | PDE4BRORCNR1H2NAMPTTERT | |
| SCHEMBL4008541 | 1.00 | PDE4B (0.51) | PDE4BRORCNR1H2NAMPTTERT | |
| SCHEMBL4007689 | 0.88 | PDE4B (0.49) | PDE4BRORCNR1H2NAMPTTACR1 | |
| SCHEMBL4009937 | 0.88 | PDE4B (0.49) | PDE4BRORCNR1H2NAMPTTACR1 | |
| SCHEMBL14498549 | 0.88 | PDE4B (0.49) | PDE4BRORCNR1H2NAMPTTACR1 | |
| SCHEMBL14495534 | 0.88 | PDE4B (0.49) | PDE4BRORCNR1H2NAMPTTACR1 | |
| SCHEMBL14498553 | 0.88 | PDE4B (0.49) | PDE4BRORCNR1H2NAMPTTACR1 | |
| SCHEMBL4390391 | 0.85 | RORC (0.60) | PDE4BRORCNR1H2NAMPTTACR1 | |
| SCHEMBL4007683 | 0.85 | RORC (0.60) | PDE4BRORCNR1H2NAMPTTACR1 | |
| SCHEMBL13809297 | 0.85 | RORC (0.60) | PDE4BRORCNR1H2NAMPTTACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957450-B1 | SEROTONIN TRANSPORTER (SERT) INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-06-24 | — | — | EP | disclosed |