Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.44 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | LDHA | P00338 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4331833 | 0.94 | LDHA (0.50) | TP53LMNASAE1UBA2MEN1 | |
| SCHEMBL13810395 | 0.92 | EPHX2 (0.46) | MEN1KMT2ASMN1; SMN2NPSR1POLB | |
| SCHEMBL13810399 | 0.91 | CNR1 (0.49) | LMNAMEN1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL13810393 | 0.90 | NPSR1 (0.54) | TP53LMNAMEN1KMT2AHIF1A | |
| SCHEMBL13810385 | 0.89 | SAE1 (0.46) | TP53SAE1UBA2MEN1MAPT | |
| SCHEMBL13810400 | 0.89 | SMN1; SMN2 (0.47) | TP53LMNAMEN1MAPTKMT2A | |
| SCHEMBL13810405 | 0.88 | PPARA (0.55) | PPARGPPARDPPARA | |
| SCHEMBL4331610 | 0.85 | LDHA (0.50) | TP53LMNAMEN1MAPTKMT2A | |
| SCHEMBL4334960 | 0.85 | NPSR1 (0.55) | TP53LMNAHIF1ASMN1; SMN2NPSR1 | |
| SCHEMBL4329956 | 0.84 | CNR1 (0.49) | MEN1MAPTKMT2ASMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7544835-B2 | Carboxylic acid derivative and salt thereof | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-06-09 | — | — | US | disclosed |
| US-7544835-B2 | Carboxylic acid derivative and salt thereof | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-06-09 | — | — | US | disclosed |