Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 18/20 | 0.52 |
| ▸ | JAK3 | P52333 | 6/20 | 0.52 |
| ▸ | TYK2 | P29597 | 4/20 | 0.52 |
| ▸ | JAK1 | P23458 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.48 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.48 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.48 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.48 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.48 |
| ▸ | DAPK3 | O43293 | 4/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.45 |
| ▸ | CLK2 | P49760 | 4/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.45 |
| ▸ | CDC7 | O00311 | 3/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10213932 | 0.80 | JAK2 (0.72) | JAK2JAK3TYK2JAK1MAPK1 | |
| SCHEMBL10130802 | 0.79 | JAK2 (0.60) | JAK2JAK3TYK2JAK1MAPK1 | |
| Hydrochloric Acid SCHEMBL10369298 | 0.78 | JAK2 (0.58) | JAK2JAK3TYK2JAK1MAPK1 | |
| SCHEMBL30494222 | 0.77 | CLK2 (0.62) | JAK2JAK3TYK2JAK1DAPK3 | |
| SCHEMBL26463432 | 0.77 | CLK2 (0.62) | JAK2JAK3TYK2JAK1DAPK3 | |
| SCHEMBL10213901 | 0.76 | JAK2 (0.71) | JAK2JAK3TYK2JAK1DAPK3 | |
| SCHEMBL10213929 | 0.76 | JAK2 (0.81) | JAK2JAK3TYK2JAK1DAPK3 | |
| SCHEMBL12907219 | 0.75 | JAK2 (0.68) | JAK2JAK3TYK2JAK1MAPK1 | |
| SCHEMBL4482791 | 0.74 | JAK2 (0.54) | JAK2JAK3ROCK1AURKBCDK2 | |
| SCHEMBL12907187 | 0.73 | JAK2 (0.72) | JAK2JAK3TYK2JAK1DAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765788-B1 | 3-AMINOINDAZOLE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF SGK-ASSOCIATED DISEASES | MERCK PATENT GMBH (DE) | 2009-06-03 | — | — | EP | disclosed |