Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 17/20 | 0.81 |
| ▸ | PDPK1 | O15530 | 4/20 | 0.64 |
| ▸ | JAK3 | P52333 | 4/20 | 0.64 |
| ▸ | TYK2 | P29597 | 3/20 | 0.64 |
| ▸ | JAK1 | P23458 | 1/20 | 0.64 |
| ▸ | PLK4 | O00444 | 2/20 | 0.61 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.61 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.61 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.61 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.61 |
| ▸ | CDK1 | P06493 | 2/20 | 0.61 |
| ▸ | CDK2 | P24941 | 2/20 | 0.61 |
| ▸ | MARK3 | P27448 | 2/20 | 0.61 |
| ▸ | CLK2 | P49760 | 2/20 | 0.61 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.61 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.61 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.61 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.61 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.61 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12907246 | 0.90 | JAK2 (1.00) | JAK2PDPK1JAK3TYK2JAK1 | |
| SCHEMBL3359889 | 0.90 | JAK2 (1.00) | JAK2PDPK1JAK3TYK2JAK1 | |
| SCHEMBL12907187 | 0.89 | JAK2 (0.72) | JAK2PDPK1JAK3TYK2JAK1 | |
| SCHEMBL31690865 | 0.89 | JAK2 (1.00) | JAK2PDPK1JAK3TYK2JAK1 | |
| SCHEMBL12907171 | 0.89 | JAK2 (0.72) | JAK2PDPK1JAK3TYK2JAK1 | |
| SCHEMBL10213932 | 0.89 | JAK2 (0.72) | JAK2PDPK1JAK3TYK2JAK1 | |
| SCHEMBL10213923 | 0.86 | JAK2 (0.65) | JAK2PDPK1JAK3TYK2JAK1 | |
| SCHEMBL26886503 | 0.86 | PDPK1 (0.74) | JAK2PDPK1JAK3TYK2JAK1 | |
| SCHEMBL10213915 | 0.84 | JAK2 (0.61) | JAK2PDPK1JAK3TYK2JAK1 | |
| SCHEMBL22715912 | 0.84 | JAK2 (0.71) | JAK2PDPK1JAK3TYK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120053345-A1 | Indazole Compounds | ABBOTT LABORATORIES (US) | 2012-03-01 | — | — | US | disclosed |
| US-20120053345-A1 | Indazole Compounds | ABBOTT LABORATORIES (US) | 2012-03-01 | — | — | US | disclosed |
| US-8008481-B2 | Indazole compounds | ABBVIE INC. | 2011-08-30 | — | — | US | disclosed |
| US-8008481-B2 | Indazole compounds | ABBVIE INC. | 2011-08-30 | — | — | US | disclosed |
| US-20070282101-A1 | Indazole compounds | ABBVIE INC. | 2007-12-06 | — | — | US | disclosed |
| US-20070282101-A1 | Indazole compounds | ABBVIE INC. | 2007-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070282101-A1 | Indazole compounds | CYP3A43, CYP3A7, UGT1A1 | JAK2 1822/4885PDPK1 856/4885JAK3 2399/4885 |
| US-20120053345-A1 | Indazole Compounds | CYP3A43, CYP3A7, UGT1A1 | JAK2 1822/4885PDPK1 856/4885JAK3 2399/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.