Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 10/20 | 0.74 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 3/20 | 0.65 |
| ▸ | TP53 | P04637 | 3/20 | 0.65 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | USP2 | O75604 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
| ▸ | MYC | P01106 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13833618 | 0.92 | APEX1 (0.80) | APEX1UHRF1LMNATP53RXFP1 | |
| SCHEMBL13058121 | 0.90 | APEX1 (0.76) | APEX1UHRF1LMNATP53KDM4E | |
| SCHEMBL3757868 | 0.89 | APEX1 (0.70) | APEX1UHRF1LMNATP53RXFP1 | |
| Hydrochloric Acid SCHEMBL18953084 | 0.87 | APEX1 (0.70) | APEX1UHRF1LMNATP53RXFP1 | |
| SCHEMBL4730003 | 0.87 | APEX1 (0.67) | APEX1UHRF1LMNATP53RXFP1 | |
| SCHEMBL13735042 | 0.85 | APEX1 (1.00) | APEX1UHRF1LMNATP53RXFP1 | |
| SCHEMBL1292249 | 0.85 | POLB (0.67) | APEX1UHRF1LMNATP53RXFP1 | |
| SCHEMBL14209373 | 0.85 | APEX1 (0.67) | APEX1UHRF1LMNATP53RXFP1 | |
| SCHEMBL1292581 | 0.85 | APEX1 (0.67) | APEX1UHRF1LMNATP53RXFP1 | |
| SCHEMBL3753082 | 0.85 | APEX1 (0.69) | APEX1UHRF1LMNATP53RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009077956-A2 | HETEROCYCLIC INHIBITORS OF AN Hh-SIGNAL CASCADE, MEDICINAL COMPOSITIONS BASED THEREON AND METHODS FOR TREATING DISEASES CAUSED BY THE ABERRANT ACTIVITY OF AN Hh-SIGNAL SYSTEM | ALLA CHEM, LLC (US) | 2009-06-25 | — | — | WO | disclosed |