Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 9/20 | 0.67 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | TP53 | P04637 | 2/20 | 0.62 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.61 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | MYC | P01106 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3757868 | 0.88 | APEX1 (0.70) | APEX1LMNATP53UHRF1RXFP1 | |
| SCHEMBL13833618 | 0.87 | APEX1 (0.80) | APEX1LMNATP53UHRF1RXFP1 | |
| SCHEMBL13812574 | 0.87 | APEX1 (0.74) | APEX1LMNATP53UHRF1RXFP1 | |
| Hydrochloric Acid SCHEMBL18953084 | 0.85 | APEX1 (0.70) | APEX1LMNATP53UHRF1RXFP1 | |
| SCHEMBL3753082 | 0.84 | APEX1 (0.69) | APEX1LMNATP53UHRF1RXFP1 | |
| SCHEMBL14209173 | 0.84 | APEX1 (0.64) | APEX1LMNATP53UHRF1RXFP1 | |
| SCHEMBL14233169 | 0.83 | APEX1 (0.66) | APEX1LMNATP53UHRF1RXFP1 | |
| SCHEMBL1292147 | 0.83 | APEX1 (0.66) | APEX1LMNATP53UHRF1RXFP1 | |
| SCHEMBL14209174 | 0.83 | APEX1 (0.63) | APEX1LMNATP53UHRF1RXFP1 | |
| SCHEMBL1292249 | 0.82 | POLB (0.67) | APEX1LMNATP53UHRF1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008020438-A2 | BENZOTHIAZOLYL THIENOPYRIDINE DERIVATIVES AND USES THEREOF | RIMONYX PHARMACEUTICALS LTD (IL) | 2008-02-21 | — | — | WO | claimed |
| WO-2008020438-A2 | BENZOTHIAZOLYL THIENOPYRIDINE DERIVATIVES AND USES THEREOF | RIMONYX PHARMACEUTICALS LTD (IL) | 2008-02-21 | — | — | WO | disclosed |