Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 4/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.36 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | GLS | O94925 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3857335 | 0.90 | P2RX7 (0.61) | P2RX7EPHX2NPC1RAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL1802916 | 0.89 | P2RX7 (0.60) | P2RX7EPHX2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13813810 | 0.84 | P2RX7 (0.61) | P2RX7EPHX2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1807655 | 0.83 | P2RX7 (0.62) | P2RX7EPHX2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1807797 | 0.83 | P2RX7 (0.52) | P2RX7EPHX2NPC1RAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL3842411 | 0.82 | P2RX7 (0.61) | P2RX7EPHX2NPC1RAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL3843804 | 0.82 | P2RX7 (0.51) | P2RX7EPHX2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1803938 | 0.81 | P2RX7 (0.73) | P2RX7EPHX2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3837447 | 0.78 | P2RX7 (0.63) | P2RX7EPHX2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1805790 | 0.76 | P2RX7 (0.62) | P2RX7EPHX2NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090143354-A1 | P2X7 Receptor Antagonists and Their Use | ASTRAZENECA AB (SE) | 2009-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090143354-A1 | P2X7 Receptor Antagonists and Their Use | P2RX7, P2RX1, P2RX2 | P2RX7 1/4885EPHX2 1014/4885NPC1 797/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.