Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 4/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5504618 | 0.73 | KCNA5 (0.42) | KCNA5KCNH2CHEK1ADORA1TDP1 | |
| SCHEMBL5506532 | 0.73 | KCNA5 (0.42) | KCNA5KCNH2CHEK1ADORA1TDP1 | |
| SCHEMBL1384577 | 0.70 | KCNA5 (0.59) | KCNA5KCNH2TDP1CTDSP1PTGDR2 | |
| SCHEMBL1383442 | 0.70 | KCNA5 (0.43) | KCNA5KCNH2CHEK1ADORA1TDP1 | |
| SCHEMBL5503777 | 0.70 | KCNA5 (0.45) | KCNA5KCNH2PTGDR2 | |
| SCHEMBL3122268 | 0.67 | KCNA5 (0.66) | KCNA5KCNH2ADORA1 | |
| SCHEMBL6047723 | 0.67 | KCNA5 (0.66) | KCNA5KCNH2ADORA1 | |
| SCHEMBL3122262 | 0.67 | KCNA5 (0.66) | KCNA5KCNH2ADORA1 | |
| SCHEMBL6047738 | 0.64 | KCNA5 (0.66) | KCNA5KCNH2ADORA1 | |
| SCHEMBL1381502 | 0.64 | KCNA5 (0.66) | KCNA5KCNH2ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4794446-B2 | — | — | 2011-10-19 | — | — | JP | claimed |
| EP-1667979-A4 | ISOQUINOLINE POTASSIUM CHANNEL INHIBITORS | MERCK & CO INC (US) | 2007-04-18 | — | — | EP | claimed |
| EP-1667979-A2 | ISOQUINOLINE POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2006-06-14 | — | — | EP | claimed |
| WO-2005030130-A2 | ISOQUINOLINE POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2005-04-07 | — | — | WO | claimed |
| EP-1667979-A4 | ISOQUINOLINE POTASSIUM CHANNEL INHIBITORS | MERCK & CO INC (US) | 2007-04-18 | — | — | EP | disclosed |
| EP-1667979-A2 | ISOQUINOLINE POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2006-06-14 | — | — | EP | disclosed |
| WO-2005030130-A2 | ISOQUINOLINE POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2005-04-07 | — | — | WO | disclosed |