SCHEMBL5506532

SCHEMBL5506532

N#Cc1ncc2ccc(OC[C@@H](O)C(O)OC(F)F)cc2c1-c1cccc(F)c1

nearest known ligand 0.42

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KCNA5 P22460 6/20 0.42
KCNH2 Q12809 5/20 0.42
DPP4 P27487 1/20 0.34
MGAM O43451 1/20 0.33
GAA P10253 1/20 0.33
SI P14410 1/20 0.33
MGAM2 Q2M2H8 1/20 0.33
TDP1 Q9NUW8 2/20 0.33
CTDSP1 Q9GZU7 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.32
ADORA1 P30542 1/20 0.32
CHEK1 O14757 2/20 0.32
EGLN2 Q96KS0 1/20 0.31
EGLN1 Q9GZT9 1/20 0.31
MAP4K4 O95819 1/20 0.31
GABRG2 P18507 1/20 0.30
GABRB3 P28472 1/20 0.30
GABRA5 P31644 1/20 0.30
GABRA3 P34903 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5504618 1.00 KCNA5 (0.42) KCNA5KCNH2DPP4MGAMGAA
SCHEMBL1384577 0.78 KCNA5 (0.59) KCNA5KCNH2TDP1CTDSP1
SCHEMBL1381503 0.73 KCNA5 (0.36) KCNA5KCNH2TDP1CTDSP1ADORA1
SCHEMBL1383442 0.72 KCNA5 (0.43) KCNA5KCNH2TDP1CTDSP1L3MBTL1
SCHEMBL3122268 0.69 KCNA5 (0.66) KCNA5KCNH2DPP4L3MBTL1ADORA1
SCHEMBL3122262 0.69 KCNA5 (0.66) KCNA5KCNH2DPP4L3MBTL1ADORA1
SCHEMBL6047723 0.69 KCNA5 (0.66) KCNA5KCNH2DPP4L3MBTL1ADORA1
SCHEMBL1378608 0.66 KCNA5 (0.54) KCNA5KCNH2GAAADORA1
SCHEMBL3119091 0.66 KCNA5 (0.54) KCNA5KCNH2DPP4L3MBTL1ADORA1
SCHEMBL3123340 0.66 KCNA5 (0.81) KCNA5KCNH2ADORA1EGLN2EGLN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1667979-A4 ISOQUINOLINE POTASSIUM CHANNEL INHIBITORS MERCK & CO INC (US) 2007-04-18 EP disclosed
EP-1667979-A2 ISOQUINOLINE POTASSIUM CHANNEL INHIBITORS Merck & Co., Inc. (US) 2006-06-14 EP disclosed
WO-2005030130-A2 ISOQUINOLINE POTASSIUM CHANNEL INHIBITORS MERCK & CO., INC. (US) 2005-04-07 WO disclosed