Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 13/20 | 0.33 |
| ▸ | BRAF | P15056 | 9/20 | 0.33 |
| ▸ | ABL1 | P00519 | 2/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11991580 | 1.00 | KDR (0.33) | KDRBRAFABL1OPRK1KMT2A | |
| SCHEMBL11991522 | 0.93 | ABL1 (0.33) | KDRBRAFABL1OPRK1KMT2A | |
| SCHEMBL12763836 | 0.91 | KDR (0.34) | KDRBRAFOPRK1KMT2AATM | |
| SCHEMBL11991604 | 0.89 | SMN1; SMN2 (0.34) | KDRBRAFABL1 | |
| SCHEMBL11991511 | 0.88 | PTK2 (0.32) | KDR | |
| SCHEMBL11991607 | 0.88 | THRA (0.32) | KDRBRAFABL1 | |
| SCHEMBL11991603 | 0.87 | BRAF (0.31) | KDRBRAF | |
| SCHEMBL11991579 | 0.86 | PIK3CD (0.37) | KDRBRAF | |
| SCHEMBL11991606 | 0.86 | BRAF (0.30) | KDRBRAF | |
| SCHEMBL11991494 | 0.84 | ABL1 (0.33) | KDRBRAFABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009076747-A1 | VIRAL POLYMERASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-06-25 | — | — | WO | disclosed |