Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 18/20 | 0.72 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.72 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.72 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.72 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.72 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | FLT3 | P36888 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4444438 | 0.90 | RAF1 (0.72) | RAF1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL4443071 | 0.84 | RAF1 (0.61) | RAF1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL5573447 | 0.84 | RAF1 (1.00) | RAF1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL13200526 | 0.79 | RAF1 (0.67) | RAF1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL5576394 | 0.76 | RAF1 (0.83) | RAF1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL667581 | 0.75 | RAF1 (0.85) | RAF1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL667238 | 0.75 | RAF1 (1.00) | RAF1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL769541 | 0.74 | RAF1 (0.64) | RAF1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL668361 | 0.74 | RAF1 (0.82) | RAF1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL668216 | 0.74 | RAF1 (0.77) | RAF1MAPK13MAPK12MAPK11MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090163556-A1 | GLYCINAMIDE DERIVATIVES AS RAF-KINASE INHBITORS | BUCHSTALLER HANS-PETER | 2009-06-25 | — | — | US | disclosed |
| US-7476683-B2 | e.g. N-(4-Chloro-3-trifluoro methyl phenyl)-2-[3-(4-pyridinyloxy)phenyl amino]-acetamide; serine/threonine kinase inhibitor; anticarcinogenic, antiproliferative, antidiabetic agent; autoimmune diseases; atherosclerosis, arthritis, Crohn's disease, retinopaty | MERCK PATENT GMBH (DE) | 2009-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163556-A1 | GLYCINAMIDE DERIVATIVES AS RAF-KINASE INHBITORS | ARAF, BRAF, RAF1 | RAF1 3/4885MAPK13 264/4885MAPK12 146/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.