Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 17/20 | 0.67 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.67 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.67 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.67 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.67 |
| ▸ | FLT3 | P36888 | 2/20 | 0.58 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13199940 | 0.91 | FLT3 (0.65) | RAF1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL13199989 | 0.85 | FLT3 (0.53) | RAF1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL13200000 | 0.85 | MAPT (0.53) | RAF1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL13200014 | 0.84 | FLT3 (0.53) | RAF1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL13199938 | 0.82 | FLT3 (0.55) | MAPK13MAPK12MAPK11MAPK14FLT3 | |
| SCHEMBL13200627 | 0.81 | FLT3 (0.48) | RAF1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL13200035 | 0.81 | FLT3 (0.69) | RAF1FLT3MEN1NPC1RAB9A | |
| SCHEMBL13199994 | 0.80 | FLT3 (0.47) | RAF1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL13199947 | 0.80 | FLT3 (0.53) | RAF1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL5573447 | 0.80 | RAF1 (1.00) | RAF1MAPK13MAPK12MAPK11MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |