Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 3/20 | 0.53 |
| ▸ | BCR | P11274 | 2/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.53 |
| ▸ | SRC | P12931 | 1/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 5/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 3/20 | 0.38 |
| ▸ | IGF1R | P08069 | 3/20 | 0.38 |
| ▸ | GSK3B | P49841 | 3/20 | 0.38 |
| ▸ | ABL2 | P42684 | 2/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1641719 | 0.82 | ABL1 (0.59) | ABL1BCRPDGFRBSRCPDGFRA | |
| SCHEMBL12726485 | 0.79 | ABL1 (0.53) | ABL1BCRPDGFRBSRCPDGFRA | |
| SCHEMBL13816255 | 0.79 | SYK (0.48) | ABL1BRAFAURKAIGF1RGSK3B | |
| SCHEMBL12726495 | 0.79 | ABL1 (0.50) | ABL1BCRPDGFRBSRCPDGFRA | |
| SCHEMBL12726490 | 0.77 | BRAF (0.52) | ABL1BCRPDGFRBSRCPDGFRA | |
| SCHEMBL12726496 | 0.76 | ABL1 (0.49) | ABL1BCRPDGFRBSRCPDGFRA | |
| SCHEMBL12766959 | 0.75 | ABL1 (0.48) | ABL1BCRPDGFRBSRCPDGFRA | |
| SCHEMBL1365 | 0.71 | ABL1 (1.00) | ABL1BCRPDGFRBSRCPDGFRA | |
| SCHEMBL12726212 | 0.69 | BRAF (0.58) | ABL1BCRPDGFRBSRCPDGFRA | |
| SCHEMBL5781584 | 0.69 | CCNT1 (0.54) | ABL1BCRPDGFRBSRCPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009076140-A1 | THIAZOLE AND OXAZOLE KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-18 | — | — | WO | disclosed |