Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2666157 | 0.91 | SMN1; SMN2 (0.44) | SMN1; SMN2MEN1KMT2ARAB9AALDH1A1 | |
| SCHEMBL1340298 | 0.91 | SMN1; SMN2 (0.44) | SMN1; SMN2MEN1KMT2ARAB9AALDH1A1 | |
| SCHEMBL12131724 | 0.91 | SMN1; SMN2 (0.41) | SMN1; SMN2MEN1KMT2ARAB9AALDH1A1 | |
| SCHEMBL1341594 | 0.87 | RAB9A (0.42) | SMN1; SMN2KMT2ARAB9AHTTGAA | |
| SCHEMBL1339607 | 0.85 | SMN1; SMN2 (0.62) | SMN1; SMN2RAB9AALDH1A1TDP1LMNA | |
| SCHEMBL1338734 | 0.84 | SMN1; SMN2 (0.56) | SMN1; SMN2MEN1KMT2AALDH1A1TDP1 | |
| SCHEMBL1340036 | 0.83 | SMN1; SMN2 (0.58) | SMN1; SMN2MEN1KMT2AALDH1A1TDP1 | |
| SCHEMBL1345539 | 0.83 | PDE5A (0.36) | SMN1; SMN2KMT2ARAB9AHTTGAA | |
| SCHEMBL1340220 | 0.83 | RAB9A (0.56) | SMN1; SMN2MEN1KMT2ARAB9AALDH1A1 | |
| SCHEMBL1340175 | 0.82 | SMN1; SMN2 (0.47) | SMN1; SMN2MEN1KMT2ARAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE45670-E1 | Aryl carbonyl derivatives as therapeutic agents | NOVO NORDISK A/S (DK) | 2015-09-15 | — | — | US | disclosed |
| US-7541373-B2 | Aryl carbonyl derivatives as therapeutic agents | NOVO NORDISK A/S (DK) | 2009-06-02 | — | — | US | disclosed |
| US-7541373-B2 | Aryl carbonyl derivatives as therapeutic agents | NOVO NORDISK A/S (DK) | 2009-06-02 | — | — | US | disclosed |