Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 14/20 | 0.59 |
| ▸ | BMP4 | P12644 | 2/20 | 0.52 |
| ▸ | FLT1 | P17948 | 3/20 | 0.49 |
| ▸ | FLT4 | P35916 | 3/20 | 0.49 |
| ▸ | PRKAB1 | Q9Y478 | 3/20 | 0.48 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | GAK | O14976 | 1/20 | 0.47 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.46 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.46 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.46 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.46 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.46 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.44 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.44 |
| ▸ | PAK4 | O96013 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3319815 | 0.83 | KDR (0.61) | KDRBMP4FLT1FLT4PRKAB1 | |
| SCHEMBL14424408 | 0.81 | KDR (0.85) | KDRBMP4FLT1FLT4PRKAB1 | |
| SCHEMBL4482059 | 0.80 | KDR (0.70) | KDRBMP4FLT1FLT4PRKAB1 | |
| SCHEMBL30184324 | 0.77 | KDR (0.56) | KDRBMP4FLT1FLT4PRKAB1 | |
| SCHEMBL12613502 | 0.76 | KDR (0.55) | KDRBMP4FLT1FLT4PRKAB1 | |
| SCHEMBL7610636 | 0.74 | KDR (1.00) | KDRBMP4FLT1FLT4PRKAB1 | |
| SCHEMBL25291998 | 0.73 | PRKAB2 (0.38) | KDRFLT1FLT4PRKAB1PRKAB2 | |
| SCHEMBL7618521 | 0.73 | KDR (0.77) | KDRBMP4FLT1FLT4PRKAB1 | |
| SCHEMBL7618559 | 0.73 | KDR (0.77) | KDRBMP4FLT1FLT4PRKAB1 | |
| SCHEMBL5405900 | 0.73 | KDR (0.72) | KDRBMP4FLT1FLT4PRKAB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7550470-B2 | Substituted pyrazolo[1,5-A]pyrimidines as tyrosine kinase inhibitors | MERCK & CO. INC. (US) | 2009-06-23 | — | — | US | disclosed |