Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 2/20 | 0.43 |
| ▸ | TACR1 | P25103 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | STS | P08842 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18252865 | 0.87 | GPR119 (0.47) | PDE4APDE4BPDE4CPDE4DGPR119 | |
| SCHEMBL31510733 | 0.86 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DGPR119 | |
| SCHEMBL18255018 | 0.83 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DSTS | |
| SCHEMBL18247835 | 0.83 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DSTS | |
| SCHEMBL3730368 | 0.83 | PDE4A (0.57) | RORCPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL18245067 | 0.81 | ATM (0.43) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL18244795 | 0.81 | ATM (0.43) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL3163882 | 0.81 | ATM (0.43) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL31510707 | 0.79 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DGPR119 | |
| SCHEMBL24433813 | 0.79 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4DGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7553841-B2 | Amino cyclobutylamide modulators of chemokine receptor activity | MERCK & CO., INC. (US) | 2009-06-30 | — | — | US | disclosed |