Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PNMT | P11086 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | CPB1 | P15086 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | NMT1 | P30419 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13718512 | 0.92 | NPC1 (0.40) | TAAR1NPC1ALDH1A1HTTPRKACA | |
| SCHEMBL1019870 | 0.82 | TAAR1 (0.42) | TAAR1NPC1ADRB2KDM4EALDH1A1 | |
| SCHEMBL13718529 | 0.81 | CHRM2 (0.48) | TAAR1NPC1CSNK1DMAPTTSHR | |
| SCHEMBL13718724 | 0.78 | NPC1 (0.54) | NPC1MAPTALDH1A1HTTPRKACA | |
| SCHEMBL13717937 | 0.77 | LMNA (0.43) | TAAR1NPC1MAPTALDH1A1HTT | |
| SCHEMBL13717864 | 0.77 | DYRK1A (0.49) | NPC1MAPTKDM4EALDH1A1HTT | |
| SCHEMBL1020769 | 0.77 | CYP19A1 (0.47) | NPC1MAPTALDH1A1L3MBTL1 | |
| SCHEMBL1019518 | 0.76 | NPC1 (0.42) | TAAR1NPC1KDM4EALDH1A1HTR6 | |
| SCHEMBL1021097 | 0.75 | TAAR1 (0.49) | TAAR1NPC1KDM4EALDH1A1HTR6 | |
| SCHEMBL13718036 | 0.75 | CHRM2 (0.45) | NPC1MAPTALDH1A1HTTPRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160289211-A1 | CERTAIN HETEROCYCLES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE | CYTOKINETICS INC (US) | 2016-10-06 | — | — | US | disclosed |
| US-20160289211-A1 | CERTAIN HETEROCYCLES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE | CYTOKINETICS INC (US) | 2016-10-06 | — | — | US | disclosed |
| US-9278962-B2 | Certain heterocycles, compositions thereof, and methods for their use | CYTOKINETICS, INC. (US) | 2016-03-08 | — | — | US | disclosed |
| US-9278962-B2 | Certain heterocycles, compositions thereof, and methods for their use | CYTOKINETICS, INC. (US) | 2016-03-08 | — | — | US | disclosed |
| US-20140330011-A1 | CERTAIN HETEROCYCLES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE | CYTOKINETICS, INC (US) | 2014-11-06 | — | — | US | disclosed |
| US-20140330011-A1 | CERTAIN HETEROCYCLES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE | CYTOKINETICS, INC (US) | 2014-11-06 | — | — | US | disclosed |
| US-8759380-B2 | Certain heterocycles, compositions thereof, and methods for their use | CYTOKINETICS, INC. (US) | 2014-06-24 | — | — | US | disclosed |
| US-8759380-B2 | Certain heterocycles, compositions thereof, and methods for their use | CYTOKINETICS, INC. (US) | 2014-06-24 | — | — | US | disclosed |
| US-20130060025-A1 | CERTAIN HETEROCYCLES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE | ASHCRAFT LUKE W (US) | 2013-03-07 | — | — | US | disclosed |
| US-20130060025-A1 | CERTAIN HETEROCYCLES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE | ASHCRAFT LUKE W (US) | 2013-03-07 | — | — | US | disclosed |
| US-20120289698-A1 | CERTAIN HETEROCYCLES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE | CYTOKINETICS, INC. | 2012-11-15 | — | — | US | disclosed |
| US-20120289698-A1 | CERTAIN HETEROCYCLES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE | CYTOKINETICS, INC. | 2012-11-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140330011-A1 | CERTAIN HETEROCYCLES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE | F12, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, ZYX | TAAR1 2267/4885NPC1 864/4885CSNK1D 213/4885 |
| US-20120289698-A1 | CERTAIN HETEROCYCLES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE | F12, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, ZYX | TAAR1 2267/4885NPC1 864/4885CSNK1D 213/4885 |
| US-20160289211-A1 | CERTAIN HETEROCYCLES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE | F12, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, C1S | TAAR1 2145/4885NPC1 897/4885CSNK1D 245/4885 |
| US-20130060025-A1 | CERTAIN HETEROCYCLES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE | F12, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, ZYX | TAAR1 2267/4885NPC1 864/4885CSNK1D 213/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.