Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCK | P08631 | 4/20 | 0.51 |
| ▸ | BTK | Q06187 | 3/20 | 0.51 |
| ▸ | ABL1 | P00519 | 13/20 | 0.48 |
| ▸ | BCR | P11274 | 12/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | GPR39 | O43194 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20925396 | 0.87 | ABL1 (0.55) | HCKBTKABL1BCR | |
| SCHEMBL3427503 | 0.84 | HCK (0.49) | HCKBTKABL1BCRKDR | |
| SCHEMBL3395506 | 0.81 | ABL1 (0.67) | HCKBTKABL1BCR | |
| SCHEMBL16609188 | 0.77 | ABL1 (0.60) | HCKBTKABL1BCR | |
| SCHEMBL16373769 | 0.72 | BRAF (0.48) | HCKABL1BCR | |
| SCHEMBL3397844 | 0.72 | BRAF (0.55) | HCKABL1BCR | |
| SCHEMBL16363369 | 0.71 | ABL1 (0.50) | HCKBTKABL1BCR | |
| SCHEMBL3402304 | 0.70 | ABL1 (0.73) | HCKBTKABL1BCR | |
| SCHEMBL3236369 | 0.70 | BRAF (0.60) | HCKKDR | |
| SCHEMBL1823911 | 0.69 | BRAF (0.61) | HCKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009073153-A2 | SMALL MOLECULE MYRISTATE INHIBITORS OF BCR-ABL AND METHODS OF USE | DANA FARBER CANCER INSTITUTE (US) | 2009-06-11 | — | — | WO | disclosed |