Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 15/20 | 0.55 |
| ▸ | BCR | P11274 | 14/20 | 0.55 |
| ▸ | HCK | P08631 | 4/20 | 0.53 |
| ▸ | BTK | Q06187 | 3/20 | 0.53 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13820441 | 0.87 | HCK (0.51) | ABL1BCRHCKBTK | |
| SCHEMBL3395506 | 0.87 | ABL1 (0.67) | ABL1BCRHCKBTK | |
| SCHEMBL3427503 | 0.86 | HCK (0.49) | ABL1BCRHCKBTK | |
| SCHEMBL16609188 | 0.82 | ABL1 (0.60) | ABL1BCRHCKBTK | |
| SCHEMBL16373769 | 0.76 | BRAF (0.48) | ABL1BCRHCK | |
| SCHEMBL3397844 | 0.76 | BRAF (0.55) | ABL1BCRHCK | |
| SCHEMBL16363369 | 0.74 | ABL1 (0.50) | ABL1BCRHCKBTK | |
| SCHEMBL3402304 | 0.73 | ABL1 (0.73) | ABL1BCRHCKBTK | |
| SCHEMBL6402301 | 0.71 | ABL1 (1.00) | ABL1BCR | |
| SCHEMBL18696372 | 0.71 | ABL1 (0.76) | ABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3150593-B1 | SMALL MOLECULE MYRISTATE INHIBITORS OF BCR-ABL AND METHODS OF USE | DANA FARBER CANCER INST INC (US) | 2019-04-24 | — | — | EP | disclosed |