Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 2/20 | 0.39 |
| ▸ | NOS1 | P29475 | 2/20 | 0.39 |
| ▸ | NOS2 | P35228 | 2/20 | 0.39 |
| ▸ | AKT1 | P31749 | 8/20 | 0.38 |
| ▸ | AKT2 | P31751 | 5/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13771808 | 0.80 | CYP11B1 (0.57) | CYP11B1CYP11B2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL18434392 | 0.78 | HTR2A (0.44) | CYP11B1CYP11B2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13662739 | 0.78 | CCR1 (0.52) | RPS6KA5SMN1; SMN2MAP4K4NOS3NOS1 | |
| SCHEMBL27320492 | 0.76 | AKT1 (0.48) | RPS6KA5AKT1AKT2AKT3 | |
| SCHEMBL16801759 | 0.75 | NPC1 (0.44) | CYP11B1CYP11B2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL15104643 | 0.75 | MAP4K4 (0.42) | RPS6KA5NPC1RAB9ASMN1; SMN2MAP4K4 | |
| SCHEMBL13659752 | 0.74 | MAP4K4 (0.39) | RPS6KA5CYP11B1CYP11B2RAB9AMAP4K4 | |
| SCHEMBL7563886 | 0.74 | RAB9A (0.56) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL31280939 | 0.74 | RAB9A (0.56) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL149306 | 0.74 | KDM4E (0.54) | CYP11B1CYP11B2NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2203435-B1 | 6, 11-BRIDGED BIARYL MACROLIDES | ENANTA PHARM INC (US) | 2018-07-18 | — | — | EP | disclosed |
| WO-2009075923-A2 | 6, 11-BRIDGED BIARYL MACROLIDES | ENANTA PHARMACEUTICALS, INC. (US) | 2009-06-18 | — | — | WO | disclosed |