Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 4/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.51 |
| ▸ | F10 | P00742 | 15/20 | 0.47 |
| ▸ | F11 | P03951 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL977976 | 0.93 | HDAC3 (0.51) | HDAC3HDAC1HDAC6F10HDAC2 | |
| SCHEMBL978289 | 0.90 | HDAC3 (0.47) | HDAC3HDAC1HDAC6F10PIK3CA | |
| SCHEMBL975313 | 0.90 | F10 (0.51) | HDAC3HDAC1HDAC6F10HDAC2 | |
| SCHEMBL13822776 | 0.90 | HDAC3 (0.56) | HDAC3HDAC1HDAC6F10F11 | |
| SCHEMBL978994 | 0.89 | F10 (0.47) | HDAC3HDAC1HDAC6F10 | |
| SCHEMBL977872 | 0.89 | HDAC3 (0.45) | HDAC3HDAC1HDAC6F10 | |
| SCHEMBL13822915 | 0.88 | HDAC3 (0.44) | HDAC3HDAC1HDAC6F10 | |
| SCHEMBL979080 | 0.88 | LMNA (0.44) | HDAC3HDAC1HDAC6F10 | |
| SCHEMBL978397 | 0.88 | NAMPT (0.46) | HDAC3HDAC1HDAC6F10 | |
| SCHEMBL975007 | 0.88 | F10 (0.58) | HDAC3HDAC1HDAC6F10HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2197552-B1 | NOVEL TETRAHYDROFUSEDPYRIDINES AS HISTONE DEACETYLASE INHIBITORS | 4SC AG (DE) | 2012-11-21 | — | — | EP | claimed |