Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27475240 | 0.83 | POLB (0.60) | POLBALDH1A1KDM4EPKM | |
| SCHEMBL1491115 | 0.79 | POLB (0.64) | POLBSMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL1247688 | 0.75 | POLB (0.64) | POLBSMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL4951229 | 0.75 | POLB (0.64) | POLBSMN1; SMN2NPC1RAB9ANFKB1 | |
| SCHEMBL1491089 | 0.75 | POLB (0.64) | POLBSMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL1491081 | 0.74 | POLB (0.58) | POLBSMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL1491132 | 0.74 | POLB (0.58) | POLBSMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL433371 | 0.74 | POLB (1.00) | POLBSMN1; SMN2NPC1RAB9ANFKB1 | |
| SCHEMBL1491136 | 0.74 | POLB (0.69) | POLBSMN1; SMN2NFKB1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL11470266 | 0.73 | POLB (0.62) | POLBSMN1; SMN2NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2203435-B1 | 6, 11-BRIDGED BIARYL MACROLIDES | ENANTA PHARM INC (US) | 2018-07-18 | — | — | EP | disclosed |
| WO-2009075923-A2 | 6, 11-BRIDGED BIARYL MACROLIDES | ENANTA PHARMACEUTICALS, INC. (US) | 2009-06-18 | — | — | WO | disclosed |