Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 7/20 | 0.50 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | GRK2 | P25098 | 4/20 | 0.40 |
| ▸ | GRK3 | P35626 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.40 |
| ▸ | GALR3 | O60755 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13972318 | 0.83 | RAF1 (0.48) | RAF1RIPK2GRK2GRK3ALDH1A1 | |
| SCHEMBL4441367 | 0.83 | RAF1 (0.73) | RAF1RIPK2ADORA3ADORA2AADORA2B | |
| SCHEMBL14136181 | 0.78 | RAF1 (0.50) | RAF1RIPK2GRK2GRK3ALDH1A1 | |
| SCHEMBL4444438 | 0.75 | RAF1 (0.72) | RAF1RIPK2MAPK13 | |
| SCHEMBL13823425 | 0.73 | GRK2 (0.53) | RAF1RIPK2GRK2GRK3ROCK2 | |
| SCHEMBL4442571 | 0.73 | RAF1 (0.62) | RAF1RIPK2GRK2GRK3ROCK2 | |
| SCHEMBL14402898 | 0.69 | RAF1 (0.48) | RAF1RIPK2ROCK2KMT2A | |
| SCHEMBL937763 | 0.68 | RAF1 (0.70) | RAF1RIPK2ALDH1A1MAPK13 | |
| SCHEMBL937764 | 0.67 | RAF1 (0.66) | RAF1RIPK2MAPTMAPK13 | |
| SCHEMBL667897 | 0.67 | RAF1 (1.00) | RAF1RIPK2ALDH1A1MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090163556-A1 | GLYCINAMIDE DERIVATIVES AS RAF-KINASE INHBITORS | BUCHSTALLER HANS-PETER | 2009-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163556-A1 | GLYCINAMIDE DERIVATIVES AS RAF-KINASE INHBITORS | ARAF, BRAF, RAF1 | RAF1 3/4885RIPK2 491/4885ADORA3 1855/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.