Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 4/20 | 0.50 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | GRK2 | P25098 | 4/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.40 |
| ▸ | GALR3 | O60755 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4444438 | 0.83 | RAF1 (0.72) | RAF1RIPK2 | |
| SCHEMBL13972318 | 0.83 | RAF1 (0.48) | RAF1RIPK2ALDH1A1MAPTKMT2A | |
| SCHEMBL4441367 | 0.78 | RAF1 (0.73) | RAF1RIPK2ALDH1A1MAPTKMT2A | |
| SCHEMBL13823410 | 0.78 | RAF1 (0.50) | RAF1RIPK2ALDH1A1MAPTKMT2A | |
| SCHEMBL4443071 | 0.74 | RAF1 (0.61) | RAF1RIPK2GRK2GRK3 | |
| SCHEMBL13815845 | 0.73 | RAF1 (0.72) | RAF1RIPK2KMT2ANPC1RAB9A | |
| SCHEMBL13823425 | 0.73 | GRK2 (0.53) | RAF1RIPK2LMNAGRK2ROCK2 | |
| SCHEMBL937763 | 0.69 | RAF1 (0.70) | RAF1RIPK2ALDH1A1LMNA | |
| SCHEMBL4442571 | 0.69 | RAF1 (0.62) | RAF1RIPK2GRK2ROCK2GRK3 | |
| SCHEMBL4445772 | 0.68 | CDK8 (0.56) | RAF1RIPK2ALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1531817-B1 | GLYCINAMIDE DERIVATIVES AS RAF-KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2008-07-30 | — | — | EP | disclosed |