Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.34 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1341059 | 0.89 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1TDP1LMNANPC1 | |
| SCHEMBL1341012 | 0.87 | RAB9A (0.35) | SMN1; SMN2ALDH1A1TDP1LMNANPC1 | |
| SCHEMBL1340014 | 0.84 | GCK (0.38) | SMN1; SMN2LMNANPC1RAB9AMEN1 | |
| SCHEMBL1339265 | 0.81 | MAPK13 (0.37) | SMN1; SMN2ALDH1A1LMNANPC1RAB9A | |
| SCHEMBL1338734 | 0.79 | SMN1; SMN2 (0.56) | SMN1; SMN2ALDH1A1TDP1LMNANPC1 | |
| SCHEMBL1339120 | 0.79 | RAB9A (0.45) | SMN1; SMN2ALDH1A1TDP1LMNANPC1 | |
| SCHEMBL1340206 | 0.79 | RAB9A (0.41) | SMN1; SMN2LMNANPC1RAB9AMEN1 | |
| SCHEMBL1340036 | 0.79 | SMN1; SMN2 (0.58) | SMN1; SMN2ALDH1A1TDP1LMNANPC1 | |
| SCHEMBL1343689 | 0.78 | SMN1; SMN2 (0.37) | SMN1; SMN2ALDH1A1TDP1LMNANPC1 | |
| SCHEMBL1341181 | 0.78 | SMN1; SMN2 (0.39) | SMN1; SMN2ALDH1A1TDP1LMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7541373-B2 | Aryl carbonyl derivatives as therapeutic agents | NOVO NORDISK A/S (DK) | 2009-06-02 | — | — | US | disclosed |